Chinese Academy of Sciences

China University of Geosciences (Beijing)

Minmin Liang

Fei Wang

Jing Feng

Feng Feng

Qi An

Kelong Fan

Xiyun Yan

Yihe Zhang

Wangshu Tong

Demin Duan

Dexi Zhang

Dongling Yang

Peixia Wang

Di Lu

A method for using a natural attapulgite is disclosed. The method includes using the natural attapulgite as a natural nano mineral enzyme. The results of the examples show that the natural attapulgite has peroxidase-like activity, catalase-like activity or superoxide dismutase-like activity, and good biocompatibility. Compared with protease, the natural attapulgite has the advantages such as large reserves, easy to obtain, low cost, high temperature resistance and wide range of pH value. Compared with a developed artificial nano enzymes, the natural attapulgite further has the advantages such as multi-function, natural non-toxic (from nature, no heavy metals), good biocompatibility, easy to obtain, no complex processing, and huge surface area which provides a place for cell growth and proliferation.

Use of natural attapulgite as natural nano mineral enzyme

The present disclosure relates to a tumor-targeted drug delivery system, comprising a tumor-targeted drug carrier and a tumor-treating drug, wherein the tumor-targeted drug carrier comprises full heavy-chain human ferritin. The present disclosure also relates to a method for preparing the tumor-targeted drug delivery system comprising: depolymerizing a polymerized full heavy-chain human ferritin; adding a tumor-treating drug to the depolymerized full heavy-chain human ferritin so as to bind the tumor-treating drug to the depolymerized full heavy-chain human ferritin; and re-polymerizing the depolymerized full heavy-chain human ferritin bound with the tumor-treating drug to form a nanoparticle.

Drug carrier for tumor-specific targeted drug delivery and use thereof

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Beijing, China

Minmin Liang