Genequantum Healthcare (suzhou) Co., Ltd.

Genequantum Healthcare Co., Ltd.

Mingyu Hu

Gang Qin

Paul H Song

Guangming Chen

Tony Yantao Zhang

Boyu Zhong

Meijun Xiong

The present disclosure further relates to a linker-payload compound including an oligosaccharide group, especially a disaccharide group, where the oligosaccharide group is linked to the remainder of the compound by an amide bond. The present disclosure further relates to an antibody-drug conjugate (ADC) containing the linker-payload compound, where the glycan chain in an antibody is remodeled with the oligosaccharide moiety in the linker-payload compound. The present disclosure further relates to preparation methods and use of the above-mentioned substances.

Oligosaccharide linker, linker-payload comprising the same and glycan chain-remodeled antibody-drug conjugate, preparation methods and uses thereof

The present disclosure relates to the biopharmaceutical field, in particular, Exatecan derivatives, linker-payloads, and conjugates and thereof antibody-drug conjugates, and the corresponding preparing process and use thereof.

Exatecan derivatives, linker-payloads, and conjugates and thereof

The present disclosure relates to a linker molecule for targeting molecule-drug conjugate, and the corresponding conjugate, the preparation and use thereof.

Linkers, conjugates and applications thereof

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Suzhou, China

Mingyu Hu