Shenzhen Neptunus Pharmaceutical Co., Ltd.

Mingyi Wu

Yuan Gao

Hui Kang

Lin Yu

Hanlin Feng

Zi Li

Zhiguo Wang

Jing Cui

Jinhua Zhao

Weizhen Zeng

Disclosed is a depolymerized glycosaminoglycan from(dTHG), weight average molecular weight of which is about 8000&#x2dc;20000 Da, and monosaccharide components of which are acetylgalactosamine (GalNAc), glucuronic acid (GlcUA), fucose (Fuc) or their sulfates (expressed as &#x2014;OSO), in which molar ratio of GalNAc:GlcUA:Fuc:&#x2014;OSOis about 1:(1&#xb1;0.3):(1&#xb1;0.3):(3.5&#xb1;0.5). Said dTHG is a potent endogenous inhibitor of factor X, which has good anticoagulant and antithrombotic activity, and can be used for the prevention and/or treatment of thrombotic diseases. Also provided is a method for preparing said dTHG, which comprises steps of 1) extracting and obtaining fucosylated glycosaminoglycan (THG) from the body wall of; 2) depolymerizing THG to obtain dTHG by method of peroxide depolymerization or method of peroxide depolymerization catalyzed by catalyst of the fourth period transition metal ions; 3) removing impurities with lower and/or higher molecular weight in dTHG.

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Mingyi Wu