Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Mingwei Zhou

Yongfu Liu

Hong Shen

Xianfeng Lin

Wei Zhu

Xuefei Tan

Taishan Hu

Lei Guo

Guolong Wu

Shixiang Yan

Houguang Shi

Bernd Kuhn

Johannes Aebi

Hans Peter Maerki

Benoit Hornsperger

Kurt E Amrein

Zhisen Zhang

Buyu Kou

Lichun Feng

Weixing Zhang

Mengwei Huang

Alexander Mayweg

Lisha Wang

Yimin Hu

Wenming Chen

Li Chen

Peter Mohr

Rainer Eugen Martin

Buelent Kocer

Haixia Liu

Alexander V Mayweg

Hongying Yun

Jim Zhen Wu

Gangqin Li

Henner Knust

Jun Wu

Michelangelo Scalone

Yun He

Zhiwei Zhang

Fabian Dey

Xiao Ding

Guozhi Tang

Chengang Zhou

Serena Maria Fantasia

Zongxing Qiu

Dongbo Li

Zhanguo Wang

Yongqiang Liu

Maarten Vercruysse

The invention provides novel compounds having the general formula: wherein R, R, R, R, R, R, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The present invention relates to novel compounds of formula (I), 

Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection

The invention provides novel compounds having the general formula: wherein R, R, Rand Rare as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.

6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, A, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.

3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds

The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, A, B, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula: wherein R, R, R, Rand A are as described herein, compositions including the compounds and methods of using the compounds.

6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, R, R, R, R, R, R, R, A, AAand n are as described herein, compositions including the compounds and methods of using the compounds. The compounds of the present invention are useful as inhibitors of aldosterone synthase. The compounds may be used, for example, in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

Bicyclic dihydroquinoline-2-one derivatives

The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, R, R, A, Aand Aare as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

Dihydroquinoline-2-one derivatives

The invention provides novel compounds having the general formula (I) wherein R, R, R, R, R, R, A, A, A, A, Aand n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

Bicyclic dihydroisoquinoline-1-one derivatives

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein Rto R, Ato Ahave the are as described herein and compositions including the compounds.

Tetrahydroquinoline derivatives

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Shanghai, China

Mingwei Zhou