Quanterix Corporation

Beth Israel Deaconess Medical Center, Inc.

Mingwei Zhao

David C Duffy

Linan Song

Dandan Shan

Nira Pollock

Ciaran Kelly

Ciaran Keely

Ultrasensitive and quantitative assays for detecting toxins of, which may involve digital ELISA, are provided. Also provided herein are differential detection assays that allow for distinguishing toxin B of highly virulentstrains from toxin B of less virulent strains.

Immunoassays for differential detection of clostridium difficile

Described herein are methods and systems for detecting DNA or RNA using single molecules array or other techniques. DNA or RNA from the sample may be fragmented and exposed to a first type of binding ligand and a second type of binding ligand that comprise nucleic acid sequences complimentary at least a portion of a sequence contained in the target DNA or RNA. At least a portion of the fragmented DNA or RNA associates with at least one of the first type of binding ligand and/or the second type of binding ligand, wherein the first type of binding ligand and second type of binding ligand comprises nucleic acid sequences complimentary to a different portions of a sequence contained in the DNA or RNA. A portion of the sample exposed to the binding ligands is analyzed to determine the number of fragmented DNA or RNA sequences.

Detection of DNA or RNA using single molecule arrays and other techniques

Growing community of inventors

Wellesley, MA, United States of America

Mingwei Zhao