Duke University

Mingtao Zhao

Joseph A Izatt

Anthony Kuo

Hansford Hendargo

Anthony N Kuo

Methods and computer program products for quantitative three-dimensional ('3D') image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography ('OCT') dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography

In accordance with this disclosure, methods, systems, and computer readable media for synthetic wavelength-based phase unwrapping in optical coherence tomography are provided. Synthetic wavelength phase unwrapping can be applied to OCT data and can correctly resolve sample motions that are larger than &#x3bb;/2. A method for phase unwrapping of an OCT signal can include acquiring raw OCT signal data, interpolating and processing the OCT signal data to obtain a DC spectrum, comparing the raw OCT signal data to the DC spectrum to generate an interference signal, applying Gaussian windows to the interference signal to generate a two separate signals, extracting phase information from the two signals, and comparing the phase information of the two signals to produce unwrapped phase data. A value of 2&#x3c0; can be added to the phase data if the difference between the phase information of the two signals is less than zero.

Methods, systems, and computer readable media for synthetic wavelength-based phase unwrapping in optical coherence tomography and spectral domain phase microscopy

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Durham, NC, United States of America

Mingtao Zhao