Sichuan Kelun-biotech Biopharmaceutical Co., Ltd.

Sichuan Keiun-biotech Biopharmaceutical Co., Ltd.

Mingliang Zhao

Jingyi Wang

Lichun Wang

Qiang Tian

Jiaqiang Cai

Hong Zeng

Wei Zhong

Hongmei Song

Shuai Song

Donghai Su

Yongyong Wu

Haitao Huang

Hua Deng

Xin Zhou

Yuting Tan

Nan Yu

Yufeng Liang

Yao Liu

Guoqing Zhong

Chengxi Yang

Wei Liu

Tianming Wang

Yan Qing

Jianhua Ge

Chaolei Wang

Baolei Zhang

Gang Liu

Wenjia Li

Donghong Li

Shaohua Li

Xunwei Wu

Long Yang

Lei Wu

Yitao Zhang

Yongjia Hao

Jiangfeng Zhou

Fulu Zhao

Jianfeng Han

Hong Ye

Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like. 

Nitrogen-containing benzoheterocycle compound comprising carboxylic acid group, preparation method and use thereof

The present invention relates to compounds represented by formula (I) and formula (II) and a chiral synthesis and chiral isolation method therefor, further relating to a salt and crystal form of the compound represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the preparation of a medicament used for the treatment of a viral infectious disease such as hepatitis B. 

Phosphonamide ester compound, salt thereof, related crystal form thereof, preparation method therefor and use thereof

The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with &#x3ba;-opioid receptor. The polyamide compound of the invention has excellent &#x3ba;-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain. The compound of the invention has higher selectivity for a &#x3ba;-opioid receptor, lower addictiveness, improved pharmacokinetic properties, and improved safety (lower toxicity and/or fewer side effects), good patient compliance, and/or lesser propensity for developing tolerance, among other excellent medicinal properties.

Polyamide compound and use thereof

Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.

Nucleoside phosphate compound and preparation method and use thereof

The present invention relates to a solid form of a compound of Formula (I), a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and the use of the solid form in the treatment of a disease involving abnormal cell proliferation or a viral infectious disease. 

Solid form of 4'-thio-2&#x2032;-fluoronucleoside phosphamide compound and preparation method therefor and use thereof

The present invention relates to a novel compound of 4'-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4&#x2032;-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.

Compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof

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Sichuan, China

Mingliang Zhao