Dalian University of Technology

Dalian Chromas Bioscience Co., Ltd.

Dalian Chromas Biosctence Co., Ltd

Mingle Li

Xiaojun Peng

Jiangli Fan

Jingyun Wang

Qichao Yao

Jianjun Du

Saran Long

Haidong Li

Yana Bian

Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.

Oxazine compound and application thereof

A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, Rand Rare independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; Ris selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and Lis a linker selected from &#x2014;(CH)&#x2014; or &#x2014;(CHCHO)&#x2014;. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy. 

Photosensitizer and derivatives and application thereof

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Liaoning, China

Mingle Li