Schering Corporation

Pharmacopeia Inc.

Cephalon, Inc.

Pharmacopeia Drug Discovery, Inc.

Merck Sharp + Dohme Corp.

Minglang Wu

John J Baldwin

Arthur G Taveras

Younong Yu

Purakkattle J Biju

Jianhua Chao

J Robert Merritt

Gaifa Lai

Ge Li

Cynthia J Aki

Evan A Hecker

Robert L Hudkins

Edward R Bacon

Michael P Dwyer

Tao Guo

Allison L Zulli

Ming Tao

Nadine C Becknell

Junying Zheng

Reddeppa Reddy Dandu

Jianping Chao

Chia-Yu Huang

Daniel Lundell

Johan A Ferreira

Babu G Sundar

Bernd Kaiser

Jay S Fine

Richard W Bond

Lisa Guise-Zawacki

Laura L Rokosz

James P Jakway

Kingsley H Nelson, Jr

Angelo Reggiani

James Jakway

The present invention provides compounds of Formula (I): their use as Hantagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.

Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands

Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula IA.

Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC-chemokine receptor ligands

Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

Isothiazole dioxides as CXC- and CC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

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Monmouth Junction, NJ, United States of America

Minglang Wu