Biosion, Inc.

Mingjiu Chen

Hongjiang Xu

Xiaofang Zou

Zhengping Zhang

Shukai Xia

Wei Tan

Cathy Xiaoyan Zhong

Wei Song

MONOCLONAL ANTIBODIES WHICH BIND THYMIC STROMAL LYMPHOPOIETIN (TSLP), ENCODING POLYNUCLEOTIDES THEREOF AND METHODS OF USE THEREOF TO TREAT DISEASES

An isolated monoclonal antibody that specifically binds human Siglec15, or an antigen-binding portion thereof. A nucleic acid molecule encoding the antibody or antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or antigen-binding portion thereof are also provided. The present disclosure further provides an immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus and a pharmaceutical composition comprising the antibody or antigen-binding portion thereof, as well as a treatment method using the same.

Antibodies binding Siglec15 and uses thereof

Provided is binding protein comprising an antigen binding fragment that specifically binds receptor tyrosine-protein kinase ErbB-2 (ErbB2), polynucleotides encoding the binding protein, vectors comprising the polynucleotides, pharmaceutical composition comprising the binding protein as well as methods of using the binding protein. The binding protein can be used for treating a disease or disorder, in which an ErbB2 activity is detrimental or inhibiting growth of ErbB2 positive cells or tumors synergistically with another ErbB2 antibody such as Trastuzumab. The binding protein can also be used for enhancing internalization of an agent or another ErbB2 antibody, for example, Trastuzumab, into ErbB2 positive cells.

ErbB2 antibodies and uses therefore

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Nanjing, China

Mingjiu Chen