Purdue Research Foundation

University of Florida Research Foundation Inc

Harvard College

Indiana University

The Broad Institute, Inc.

Howard Hughes Medical Institute

Mingji Dai

Mohamed Seleem

Dexter Cameron Davis

Haroon Taj Mohammad

Zhishi Ye

Ji-Xin Cheng

Zhong-Yin Zhang

Val J Watts

Alexander Adibekian

Dominic Gregor Hoch

Xianglin Yin

Stuart L Schreiber

Jian-Ting Zhang

Drew Adams

Jing-Yuan Liu

Zarko Boskovic

Hunter Sims

Kwaku Kyei-Baffour

Mahmud Mustaqim Hussain

Methods for the synthesis of a tricyclic-prostaglandin Dmetabolite methyl ester or a pharmaceutically acceptable salt thereof.

Methods for synthesis of the tricyclic prostaglandin Dmetabolite methyl ester

One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same

Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification.

Survivin-targeting anti-tumor agents and uses thereof

The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.

Sesquiterpenoid analogs

The present disclosure relates to novel synthetic method of making 1, 4-diazo N-heterocycles via intermolecular amphoteric diamination of allenes, and to the compounds made by the novel synthetic method.

Methods for 1,4-diazo N-heterocycle synthesis

A method of forming a probe, wherein the method includes converting cholenic acid into a compound with a terminal alkyne group, wherein the converting the cholenic acid comprises using a sequence, wherein the sequence comprises synthesizing a THP-protection group, LiAlH4 reduction, Dess-Martin oxidation, and Seyferth-Gilbert-Bestmann homologation. The method additionally includes forming A-Chol by removing the THP-protection. Further, the method includes forming PhA-Chol from the compound with the terminal alkyne group via a palladiumcatalyzed Sonogashira reaction. Additionally, the method includes forming PhDY Chol from the compound with the terminal alkyne group via a coppercatalyzed Cadiot-Chodkiewicz reaction.

Raman tag

The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of

Aryl isonitriles as a new class of antimicrobial compounds

Methods for 1,4-diazo n-heterocycle synthesis

Invasive fungal infections present a formidable global public health challenge due to the limited number of approved antifungal agents and the emergence of resistance to the frontline treatment options, such as fluconazole. Three fungal pathogens of significant concern are, andgiven their propensity to cause opportunistic infections in immunocompromised individuals. This disclosure provides a set of aryl isonitrile compounds that possess broad-spectrum antifungal activity primarily against species ofand. The most potent derivatives are capable of inhibiting growth of these key pathogens at concentrations as low as 0.5 &#x3bc;M. Remarkably, the most active compounds exhibit an excellent safety profile and are non-toxic to mammalian cells even at concentrations up to 256 &#x3bc;M.

Aryl isonitrile compounds as a new class of potent, broad-spectrum antifungal compounds

The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.

Adenylyl cyclase inhibitors for neuropathic and inflammatory pain

The present disclosure relates to novel lactones such as dihydropyrrole-fused furanones, a novel palladium-catalyzed carbonylation method to make the novel lactones, and method of using the novel lactones as anti-fungal and/or anti-bacteria agents.

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West Lafayette, IN, United States of America

Mingji Dai