Merck Sharp + Dohme B.v.

Akzo Nobel

Mingiang Zhang

Ronald Palin

David Jonathan Bennett

Jonathan Bennett

Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C)alkylene, optionally substituated with 1-3 OH groups, or (CH)-phenylene-(CH)&#x2014;; o and p are independently 0-4; X is COOH, CONHR, NHCOR, SOOH, PO(OH), O(CH&#x2014;CH&#x2014;O)&#x2014;H, OH or tetrazol-5-yl; Ris H or (C)alkyl; Ris carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.

6-mercapto-cyclodextrin derivatives:reversal agents for drug-induced neuromuscular block

Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m&plus;n&equals;7 or 8; R is (C )alkylene, optionally substituated with 1-3 OH groups, or (CH ) -phenylene-(CH ) &mdash;; o and p are independently 0-4; X is COOH, CONHR , NHCOR , SO OH, PO(OH) , O(CH &mdash;CH &mdash;O) &mdash;H, OH or tetrazol-5-yl; R is H or (C )alkyl; R is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.

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Montreal, Canada

Mingiang Zhang