Qilu Pharmaceutical Co., Ltd.

Minghui Zhang

Shuhui Chen

Jingyi Wang

Long Zhang

Shousheng Yan

Zhaozhong Ding

Xile Liu

Haiwen Wan

Jianrong Zhu

Baoping Zhao

Zongru Guo

Chuanwen Fan

Yingying Yang

Zhantao Zhang

Qingmin Yang

Haojie Zhou

Shansong Zheng

Dong Lin

Boyan Xu

Shaobo Yang

Ying Li

Zhongru Guo

Jinqing Hu

Qingmei Zheng

Yidong Zhu

Disclosed is a spirocyclic aryl phosphorus oxide or sulfide as an ALK inhibitor, particularly, a compound represented by formula (I) as an ALK inhibitor or pharmaceutically acceptable salt thereof. 

Spirocyclic aryl phosphorus oxide and aryl phosphorus sulfide

The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors. 

4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors

Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human). 

Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof

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Jinan, China

Minghui Zhang