Synta Pharmaceuticals Corporation

Minghu Song

Weiwen Ying

Dinesh U Chimmanamada

Shijie Zhang

Junghyun Chae

Joseph A Burlison

Zhenjian Du

Stefan M Schweizer

Kevin Paul Foley

Dan Zhou

Shuzhen Qin

Chi-Wan Lee

Lijun Sun

Zachary Demko

Howard P Ng

Keizo Koya

Teresa Przewloka

David James

Hao Li

Teresa Kowalczyk-Przewloka

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

Triazole compounds that modulate HSP90 activity

The present invention relates to substituted pyrrole compounds of formula I and compositions comprising substituted tri-substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a tri-substituted' triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

The present invention relates to compounds that inhibit the activity of Hsp90 and inhibit topoisomerase II.

Method for inhibiting topoisomerase II

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound. 

Triazinone and diazinone derivatives useful as HSP90 inhibitors

Triazole compounds that modulate Hsp90 activity

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Chester Springs, PA, United States of America

Minghu Song