Medtronic Vascular, Inc.

Kerr Corporation

Warsaw Orthopedic, Inc.

Medtronic, Inc.

Covidien LP

Mingfei Chen

Kishore Udipi

Peiwen Cheng

Christos Angeletakis

Josee Roy

Christopher W Storment

Hezi-Yamit Ayala

Carol Sullivan

David Shumaker

Gerald N Hodgkinson

Michael Gloss

Mike Krivoruchko

Ayala Hezi-Yamit

Karan Punga

Ya Guo

William W Chang

Brian Castelli

Matthew Baldwin

Salvador Avelar

Brian Graham

Emily E Jacobs

Todd Grodrian

Joseph A Traina

Su-Ping Lyu

Rhonda L Staneart

Monideepa Chatterjee

Evaldas Karciauskas

David A Shumaker

Mark M Wegner

Brian J Castelli

Karan P Punga

Michael A Gloss

A method of forming an electrospun prosthetic valve includes utilizing a rotatable and angularly adjustable prosthetic valve mold. The prosthetic valve mold is set to a first angle. The prosthetic valve mold is rotated at a first rotational velocity and a first layer of electrospun fibers is deposited on the prosthetic valve mold. The prosthetic valve mold is stopped and a frame is positioned over the first layer. The prosthetic valve mold is set to a second angle. The prosthetic valve mold is rotated at a second velocity and a second layer of electrospun fibers is deposited on an outer surface of the first layer and an outer surface of the frame.

Electrospun medical devices and methods of making electrospun medical devices

Devices including a capsule having an interior and a clamp assembly including a plurality of clamps. Each clamp includes a first arm having a first free end and a second arm having a second free end. The device includes a clamp assembly including a compacted state in which the plurality of clamps are compressed within the capsule and a deployed state in which at least the free ends of the plurality of clamps are positioned outside of the interior of the capsule. The first free end is closer to the second free end in the compacted state as compared to the deployed state. The device can further include a push rod releasably secured to the clamp assembly and a delivery rod releasably secured to the capsule. Methods of using the devices are also disclosed.

Ligating devices and methods for heart valve repair

Surgical stapling devices have a surgical buttress attached to an anvil jaw member, a cartridge jaw member, or both. In use, the surgical buttress reinforces a staple line formed upon application of staples from the surgical stapling device and minimizes leaks which may exude from the staple line and/or tissue being stapled by the surgical stapling device.

Surgical medical devices

A medical device, such as a dilatation balloon, including plasticized nylon, and plasticized nylon.

Medical device and plasticized nylon

A plasticized nylon and a medical device including plasticized nylon. The medical device may be a dilatation balloon. Also disclosed are methods of plasticizing nylon.

Medical device and plasticized nylon material

The present disclosure generally relates to biocompatible polymers for coating or fabricating implantable medical devices and to implantable medical devices having the present biocompatible polymers. The disclosed biocompatible polymers exhibit superior biocompatibility and therefore minimize unwanted immune reaction from a patient into whom a medical device is implanted.

Biocompatible polymers for coating or fabricating implantable medical devices

Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug.

Medical devices comprising polymeric drug delivery systems with drug solubility gradients

In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.

Compositions and methods for treating a damaged cardiovascular element

Biodegradable polymers useful for fabricating implantable medical devices and as coatings for medical devices are provided. The biodegradable polymers are biocompatible and can be tuned to provide optimum bioactive agent elution rates as well as degradation rates. Also provided are methods for making medical devices and medical device coatings using the biodegradable polymers.

Medical devices and coatings therefore comprising biodegradable polymers with enhanced functionality

The present disclosure in a broad aspect provides for diazeniumdiolated phosphorylcholine polymers and associated methods for achieving nitric oxide release. The present polymers have superior biocompatibility and are useful for coating or fabricating medical devices such as a vascular stent.

Diazeniumdiolated phosphorylcholine polymers for nitric oxide release

Biocompatible polymers having polymer backbones with at least one secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-opening reactions are provided. More specifically, nitric oxide-releasing medical devices made using these polymers are disclosed.

Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation

Disclosed are hindered amine nitric oxide (NO) donating polymers for coating implantable medical devices. The polymers include sterically hindered secondary amines that do not react with monomer carbonyls or electrophilic alkenes, facilitating the synthesis of the NO donating polymers. The polymers are coated on implantable medical devices, providing anti-restenosis therapy by the release of NO at the implantation site.

Hindered amine nitric oxide donating polymers for coating medical devices

Growing community of inventors

Santa Rosa, CA, United States of America

Mingfei Chen