Ford Global Technolgoies, LLC

Nanjing University of Chinese Medicine

Ming Zhao

Le Hong

Seven Qi

Jinao Duan

Sheng Guo

Lu Fan

Di Di

Cai Lu

Shulan Su

Mingming Xu

Lawrence Wu

Junfei Zhou

The invention discloses a (9β-H)-pimarane skeleton diterpenoids with anti-colon cancer activity and a derivative thereof, and further discloses a preparation method and application of the compounds above; the invention finds that novel skeleton compounds 1 and 2 have certain inhibition effects on colon cancer cells, wherein the compound 2 has remarkable anti-proliferation effects on two colon cancer cell lines HT-29 and SW620, and the effects are both stronger than those of a positive drug 5-fluorouracil, so that the compound has the potential of being developed into a new anti-colon cancer drug.

(9beta-H)-pimarane mother nucleus diterpenoid compound with anti-colon cancer activity and derivative thereof, and preparation method thereof

A pipe retaining device comprises a base panel; a clamping member coupled to the base panel and including a flexible part; and an adjusting member disposed outside the clamping member. The adjusting member includes a plurality of retaining portions adjacent to the flexible part and is moveable relative to the clamping member such that the flexible part is selectively engaged with one of the retaining portions.

Pipe retaining devices

Growing community of inventors

Nanjing, China

Ming Zhao