University of Macau

The Hong Kong Polytechnic University

Ming Yuen Lee

Zaijun Zhang

Guodong Yu

Guohui Li

Cheuk-Wing Li

Yifan Han

Chung Lit Choi

Wei Cui

TatFong Ng

Jingyun Jiang

Disclosed are compositions and methods for treatment of a disease or disorder of the eye and adnexa of the eye, including dry eye disease and Sj&#xf6;gren's syndrome, by administering a composition comprising an indole and a flavonoid either as an admixture or as a synthetic heterodimer thereof.

Compositions comprising a combination of a substituted flavonoid and a substituted indole for treating ocular diseases

Provided is a microfluidic device comprising an incubation layer, the incubation layer including at least one dock, each of the at least one dock defines a stepped tank comprising an upper tank and a lower tank, an inflow channel in fluid communication with the stepped tank for supplying a fluid to the stepped tank, and an outflow channel in fluid communication with the stepped tank for draining the fluid from the stepped tank, wherein the geometry of the upper tank is configured to allow culturing of a fish larva therein, and wherein the geometry of the lower tank is configured to reversibly receive the fish larva from the upper tank and to dock the fish larva at a controlled orientation for imaging or observation.

Microfluidic screening system

This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.

Methods of treating Parkinson's disease

A microfluidic system for separating an analyte from a sample fluid including a series of fluidic channels including at least one first region and at least one second region. The first region includes a plurality of L-nodes, which connects to each other in series. The second region includes a plurality of R-nodes, which connects to each other in series. The first region is configured to trigger at least about one lamination process cycle for both the sample fluid and the buffer fluid and the second region is configured to trigger at least about one reverse lamination process cycle for both the sample fluid and the buffer fluid, whereby the lamination process cycle and the reverse lamination process cycle causes the analyte to diffuse to the buffer fluid from the sample fluid. A method for separating the analyte is also disclosed.

Microfluidics separation method and system thereof

The present invention provides a method of using indole-ketone or indolidone such as SU4312, SU5416, SU11248 (Sunitinib), or indirubin-3-oxime to treat a neurodegenerative disease or disorder such as Parkinson's disease which is associated with excessive neuronal Nitric Oxide Synthase (nNOS) activity.

Uses of indole-ketones or indolidones as neuro-protective drugs

This invention is directed to novel compounds isolated or derived fromfructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.

Growing community of inventors

Macau, China

Ming Yuen Lee