Oracle International Corporation

Peking University

Beijing Vitalstar Biotechnology Co., Ltd.

Beihao Stem Cell and Regenerative Medicine Translational Research Institute

Ming Yin

Kirankumar Nimashakavi

Guang Yang

Zhe Li

Jun Xu

Jinlin Wang

Yan Shi

Hongkui Deng

Ting Lou

Yuanyuan Du

Rotter Zeng

Nan Song

Jun Jia

Chengang Xiang

A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.

Methods for reprograming non-hepatocyte cells into hepatocyte cells

A system and method is provided for generating a RESTful communication service which offers REST2REST functionality seamlessly with automatic support for the API agnostic features such as policy enforcement, load balancing, routing, failover, logging, accounting, format conversion (XML2JSON,JSON2XML) etc. Such a system can include one or more applications, executing on one or more application servers. The system can also include a WADL plug-in which generates code for the RESTful communication service from Web Application Description Language files (WADL) which define the service interface and internal templates which define the code logic. The method offers rapid and efficient generation of REST APIs supporting API agnostic features, automatic REST API code generation from WADL files, and translation from WADL to WSDL.

System and method of generating REST2REST services from WADL

Systems and methods are described for creating composed communication services within a gateway to a telecom network. Composed communication services are virtual services which can be created by a network operator and which combine two or more actual communication services that perform functionality in the telecom network. For example, a composed messaging service can be created for a client, which combines methods from the MMS and SMS communication services. Subsequently, when the client invokes either SMS or MMS services in the gateway, those invocations will be counted against the composed service and the SLA and policy control will be applied against it accordingly.

Systems and methods for creating composed communication services

In accordance with various embodiments, systems and methods that provide for authorization of access to protected resources. Such a system can include a plurality of applications, executing on one or more application servers. The system can also include an authorization server which is operable to interface with one or more remote and/or non-co-located third party authentication servers. Each application can (a) receive a request for authorization to access a controlled resource; (b) redirect the request for authorization to a configurable authentication endpoint identifying a third party authentication server; (c) receive authorization information from the third party authorization server; and (d) issue an authorization code for access to the protected resource.

System and method of extending oauth server(s) with third party authentication/authorization

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Beijing, China

Ming Yin