Other

Cook Composites & Polymers Co.

Ccp Composites US LLC

The Medical College of Wisconsin, Inc.

Polynt Composites Usa, Inc.

Ccp Composites S.a.

Ming Yang Zhao

Chih-Pin Hsu

Li-Ming Zhou

Linda Bergstrom

Steven L Voeks

L Scott Crump

Balaraman Kalyanaraman

Micael J Hardy

Marcos Lopez

Jeremy Earl Warren

Erwoan Pezron

Frederic Bauchet

Richard Landtiser

The present disclosure provides compositions comprising artemisinin-derived trimers and tetramers; methods of preparing these compositions; and methods for their use as medicaments.

Artemisinin-derived trimers and tetramers and their use thereof

Zero VOC thermosetting gel coat and laminating resin compositions, and composites and articles, are produced using a multifunctional Michael acceptor, a multifunctional Michael donor and a base catalyst. The obtained low viscosity resin is useful for producing zero VOC gel coats and laminates having excellent curability at ambient temperatures.

Acetoacetyl thermosetting resin for gel coat

The present disclosure provides a composition of artesunate, a process of preparing the same, and a method of treatment.

Composition containing artesunate

The present disclosure provides new salts of 5-aminolevulinic acid (5-ALA) and new salts of 5-ALA esters, their preparation, formulation and use as photosensitizing agents in photodynamic therapy, diagnosis and cosmetic cares.

Salts of 5-aminolevulinic acid and derivatives

The invention relates to thermosetting compositions containing isocyanurate ring(s) prepared through chain extension of an epoxy resin (a) with carboxyl-functional oligomers (b), which are the reaction product of polyols (i) containing one or more isocyanurate ring(s) and polycarboxylic acids or their anhydrides (ii). The polyols (i) containing one or more isocyanurate ring(s) can be prepared from the reactions of tris (2-hydroxyalkyl) isocyanurates with a modifier from a caprolactone or alkylene oxide, or glycidyl ester or glycidyl ether and mixtures thereof. The epoxy-functional thermosetting compositions containing an isocyanurate ring(s) can be further reacted with unsaturated acids, preferably (meth)acrylic acid, to obtain a curable polyacrylate. Both epoxy-functional isocyanurate and acrylate-functional isocyanurate thermosetting compositions can be further modified with a polyisocyanate to produce a composition that is useful as a reactive adhesive, binder or in other applications.

Thermosetting compositions containing isocyanurate rings

A thermosetting unsaturated polyester resin (UPR) composition comprising an unsaturated polyester polymer having at least two strained cycloolefinic double bonds and optional unstrained cycloolefinic double bonds, which can be cross-linked through a ring-opening metathesis polymerization (ROMP) or combination of ROMP and cationic or free radical polymerization is provided. No styrene is used in the resin composition. The thermosetting unsaturated polyester resin composition also comprises a catalyst system for the ring-opening metathesis polymerization, and in embodiments, can further comprise one or more optional unsubstituted or substituted cycloolefin monomer containing unsaturation, an optional co-catalyst selected from a cationic initiator or free radical initiator, and optional additives. The cured resin properties can be controlled through adjusting the structure and properties of the unsaturated polyester resin.

Styrene-free unsaturated polyester

The invention encompasses radiopharmaceutical compounds that can be used in imaging cell death associated with either apoptosis or necrosis. Phosphatidylethanolamine (PtdE) is externalized to the surface of apoptotic cells, and also becomes accessible in necrotic cells due to compromised plasma membrane integrity. Duramycin, a 19 amino acid polypeptide, binds PtdE at a 1:1 ratio with high affinity and exclusive specificity. Novel Duramycin-based radiopharmaceuticals and non-radioactively labeled compounds are disclosed herein. Such compounds facilitate detection of cell apoptosis and/or necrosis by binding to PtdE. The location of the bound compound can then be pinpointed using standard imaging techniques.

99mTc-labeled 19 amino acid containing peptide for use as phosphatidylethanolamine binding molecular probe and radiopharmaceutical

Thermosetting compositions containing isocyanurate ring

Low VOC thermosetting polyester acrylic resins are made by esterification of unsaturated epoxide such as glycidyl methacrylate, and a polyacid which is the half-ester formed by reacting an acid or its anhydride with a polyol is disclosed. The obtained low viscosity resin is useful for making a low or zero VOC gel coat with excellent hydrolytic and weather resistance.

Low VOC thermosetting polyester acrylic resin for gel coat

Tc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging.Tc-Mito-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared toTc-MIBI.Tc-Mito-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.

99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors

A process to disperse organic microparticles/nanoparticles into non-aqueous resin medium is provided. The process includes the steps of a) preparing a resin dispersion/emulsion in water and/or solvent where the resin contains unsaturation in the polymer chain and optionally comprises an ethylenically unsaturated monomer; b) curing the resin dispersion/emulsion by adding monomer and/or initiator; and c) adding the cured dispersion/emulsion during a synthesis step of a resin medium. The amount of organic microparticles/nanoparticles in the resin medium can be about 2 to about 30% by weight based on the total weight of the composition.

Process to disperse organic microparticles/nanoparticles into non-aqueous resin medium

With only 19 amino acids, Duramycin is the smallest known polypeptide that has a defined 3-dimensional binding structure. Duramycin binds Phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. As an abundant binding target, PtdE is a major phospholipid and accounts for about 20% of the phospholipid content in mammalian cellular membranes. PtdE is externalized to the surface of apoptotic cells, and also becomes accessible in necrotic cells due to compromised plasma membrane integrity. Given the unique physicochemical properties of Duramycin and the availability of PtdE in acute cell death, the goal of this study is to develop and evaluateTc-HYNIC-Duramycin as a novel molecular probe for imaging PtdE. Tc-HYNIC-Duramycin is a low-molecular weight, fast-clearing radiopharmaceutical that detects apoptosis/necrosis by binding to PtdE. The goal was to quantify the uptake ofTc-HYNIC-Duramycin in the area-at-risk after myocardial ischemia and reperfusion, and to determine the window of detection.

[object Object]

A low viscosity (and therefore low VOC) resin can be produced by limiting the molar ratio of the reactants, especially the dicarboxylic acid compound, used in the reaction. Specifically, reacting a reaction mixture comprising (i) one mole of a diepoxide having at least two glycidyl ether type epoxy groups; (ii) 0.5 to 2.0 moles of an unsaturated monocarboxylic acid; (iii) 0.1 to 0.5, preferably 0.1 to 0.3, moles of maleic anhydride; and, (iv) water, until substantially all of the epoxy groups disappear leads to the formation of a resin with a high shear (at least 500 s) viscosity of less than 1200 cP when measured in a 70% NVM (non-volatile matter) styrene solution. The resin may be used in barrier coatings, gel coatings, skin coatings and as a laminate resin.

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Kansas City, MO, United States of America

Ming Yang Zhao