Arizona State University

Ming Yang

Qiang Chen

Huafang Lai

Haiyan Sun

The present invention relates to the fields of genetically modifiedstrains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modifiedstrains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologies. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.

Reducing the toxicity of agrobacterium endotoxin

Compositions including a virus-like particle (VLP)-based vaccine displaying a portion of ZIKV envelope protein (E) domain III (DIII) and a portion of ZIKV envelope protein (E) and related methods are disclosed herein. Further, compositions including vaccines comprising a portion of ZIKA virus E protein, wherein the portion of ZIKA virus E protein is either a full-length version of ZIKA virus E protein or a functionally equivalent version of the full-length ZIKA virus E protein, are disclosed.

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Chandler, AZ, United States of America

Ming Yang