Taipei Medical University

Panion & Bf Biotech Inc.

Ming-Thau Sheu

Pu-Sheng Wei

Kuo-Hsiang Chuang

Yu-Ying Hsu

Yu-De Su

Yu-Hsuan Liu

Michael Chen

Yuan-Soon Ho

Yi-Jou Chen

Jun-Jen Liu

Hsiu-O Ho

Shing Chuan Shen

Shyr-Yi Lin

Hua-Jing Jhan

Yuan Soon Ho

A method of preparing polylactic acid (PLA) microsphere and polylactic-co-glycolic acid (PLGA) microsphere is provided, including the following steps. A first solution is provided, including polylactic acid or polylactic-co-glycolic acid and an organic solvent. A second solution is provided, including polyvinyl alcohol, sodium carboxymethyl cellulose and an aqueous solution. The first solution is added to the second solution and, at the same time, the second solution is agitated until polylactic acid is solidified to form a plurality of polylactic acid microspheres, or until polylactic-co-glycolic acid is solidified to form a plurality of polylactic-co-glycolic acid microspheres. The polylactic acid microspheres or polylactic-co-glycolic acid microspheres are collected. The polylactic acid microsphere and the polylactic-co-glycolic acid microsphere are respectively the accumulation of the polylactic acid and polylactic-co-glycolic acid, having a smooth surface and a mean number particle size distribution (MN) from 10 μm to 80 μm.

Polylactic acid microsphere, polylactic-co-glycolic acid microsphere and method of preparing the same

The present disclosure relates to a biodegradable and thermosensitive hydrogel composition comprising a diblock PLGA-PEG copolymer and a triblock PLGA-PEG-PLGA copolymer. A method for treating or alleviating one or more symptoms of a disease and a method for delivering an active agent are also provided.

Hydrogel composition for drug delivery and uses thereof

The present invention relates to an anti-tumor/anti-tumor-associated fibroblast (TAF)/anti-hapten trispecific antibody (TsAb). The anti-hapten domain enables TsAb to arm various hapten-conjugated anti-cancer drugs (nanocarrier drugs, small molecule drugs, protein drugs, and radioactive drugs). The anti-tumor domain enables TsAb-armed drugs to target tumor cells, while the anti-TAF domain enables the TsAb-armed drugs to target TAFs. The present invention allows the simultaneous killing of tumor cells and TAFs by various drugs through arming with TsAb.

Anti-tumor/anti-tumor associated fibroblast/anti-hapten trispecific antibodies and use thereof

The invention develops a developed a thermosensitive injectable hydrogel based on HA and a copolymer of polyethylene oxide (PEO) and polypropylene oxide (PPO), which has a gel formation temperature from 30&#xb0; C. to 37&#xb0; C. The thermosensitive injectable hydrogel of the invention provides a potential drug delivery system that can increase therapeutic efficacy of the drug.

Thermosensitive injectable hydrogel for drug delivery

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Taipei, Taiwan

Ming-Thau Sheu