Wainamics, Inc.

Cisco Technology, Inc.

Becton Dickinson and Company Limited

Ldip, LLC

Ming Tan

Arturo M Escajeda

Huyen Tran

Edward M Goldberg

Frank G Zaugg

Wei Lun Huang

Mahesh Viveganandhan

Dan Li

Peter Kernen

Dipak Punnoran Koroth

Scott Bornheimer

Jeffrey Sugarman

Martin Andrew Ostrowski

Hrair Kirakossian

Ashutosh Shastry

Reuven Duer

Yun-Pei Chang

Christopher E Todd

Leyla Sabet

The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

System and self-metering cartridges for point of care bioassays

The invention, is directed to devices and methods for low cost and convenient separation, of plasma from whole blood. In some embodiments, devices of the invention comprise an integrated collection of channels and chambers m a body that permit acquisition of a blood sample by capillary action, centrifugal separation of cells from plasma, and manual dispensing of purified plasma by simple pinching of a bellows chamber to force air into plasma-holding channels which thereby expels a predetermined volume of the purified plasma.

Small volume self-metered blood separation device

The invention is directed to methods and devices for efficient separation of plasma irons whole blood which are suitable for point of care use in resource poor environments, in some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in Quid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into ore SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

Microscale plasma separator

The invention is directed to methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments. In some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in fluid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into the SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing of the sample and reagent without filtering the sample.

Microfluidic devices, and methods of making and using the same

Optical readers and alignment tools for detecting the level of an analyte. Described herein are small, disposable partially-encapsulated sensing chips for detecting an analyte level from a fluid sample (e.g., a blood sample) having an edge of the integrated sensing chip exposed to directly expose a plurality of excitation and a collection waveguides, as well as optical readers and methods of operating them. A fluid sample maybe applied to a sensing surface of the sensing chip in the housing so that an analyte level can be optically detected. Also described are methods of sensing an analyte using these devices and systems including an optical detector.

Partially encapsulated waveguide based sensing chips, systems and methods of use

In some embodiments, a request for a content object may be received as a data packet. Upon determining that the content object is not cached, an element of the data packet may be modified and the modified data packet may be forwarded toward a content provider of the content object.

Distributed web object identification for web caching

In one embodiment, redundancy elimination for web caching may be provided. Upon receiving a request for a content object, a determination of whether the content object is cached may be made. In response to determining that the content object is not cached, the requested content object may be retrieved and, if the content object is associated with an aggregate popularity exceeding a caching threshold, the content object may be cached before providing the requested content object.

Growing community of inventors

Danville, CA, United States of America

Ming Tan