Olin Corporation

Linden Technologies, Inc.

Shionogi Bioresearch Corporation

Ming Shen

Tai-Nang Huang

Donald L Lickei

Michael L Rosin

Yih Huang

Weimin Liu

John A Wojtowicz

Simon W Law

Haisun Liao

Shin-Yih Chen

Guiqing Liang

Amy Anderson Deik

Teresa Przewloka

Natalia Mamaeva

Shijie Zhang

Caroline Ngaara Woodward

The invention features linker molecules that have at one terminus a amino-protecting group and at the other terminus a phosphorous activating group, typically phosphoramidite. The linker molecules can be used, for example, to produce amino-modified linkers that space an oligonucleotide from a solid support. The invention also features an amino-protected nucleotide that includes an activated phosphorous group such as a phosphoramidite for the production of a 5' amino-modified oligonucleotide. The invention further provides a phthalimido-modified support that can be used to synthesize a polynucleotide that includes an amino group at the 3&#x2032; terminus.

Protected linker compounds

Disclosed is an insoluble support that can be used, for example, for producing replicates of sample nucleic acids. The support includes a plurality of attached oligonucleotides that include a prokaryotic promoter sequence and a target annealing sequence 3' of the promote. The proximal end of the promoter sequence is spaced from the insoluble support by a distance greater than 10 nm.

Nucleic acid amplification

Immobilized nucleotide primers of this invention include a modified nucleotide tethered to a support substrate through a linking group. In particular, the modified nucleotide is constructed such that the C-5&prime; end of the nucleotide is tetherable to the linking group and the protected C-3&prime; end is available for further controlled modification, e.g., addition of other nucleotides in specific sequences to the immobilized nucleotide primer. Additionally, the linking group is of sufficient length to allow the immobilized nucleotide primer to be used to synthesize and screen arrays of oligonucleotides, e.g., enzymatic C-3&prime; primer extension.

C-3&prime; protected monomeric nucleotides and synthesis of oligonucleotides on solid support

A cyanoguanidine compound of the following formula:

Cyanoguanidine compounds

The present invention is directed to a process for the preparation of polyoxyalkylene ether surfactant compositions comprising the steps of combining an admixture of alkoxylated alcohols with an acid catalyst and 1-6 molar equivalents of an aldehyde. The mixture is reacted at between about 50.degree. C. and about 180.degree. C. and at between about 1 atm and 10 atm pressure in the absence of a distillation step to produce the polyoxyalkylene ether surfactant composition.

Process for the preparation of polyoxyalkylene ether surfactant

The present invention relates to a process for producing isocyanates which comprises reacting an N-halogenated amide with an organic base in an essentially water-free modified Hofmann reaction using a soluble silver salt promoter in the presence of an organic solvent. Also disclosed is a process for producing a carbamate which comprises reacting an N-halogenated amide with an organic base in an essentially water-free modified Hofmann reaction using a soluble silver salt promoter in the presence of an alcohol solvent.

Preparation of isocyanates using a silver salt promoted rearrangement

Described herein is a process for the preparation of chlorohydrins by reacting a concentrated, aqueous solution of hypochlorous acid with at least one unsaturated organic compound having from 2 to about 10 carbon atoms and selected from the group consisting of substituted or unsubstituted olefins and cyclic olefins.

Preparation of chlorohydrins

A process for preparing water-scale inhibitors and, more specifically, a neat process for preparing acrylic acid/ethylene glycol graft co-polymers and a method for their use as scale inhibitors.

Block co-polymers useful as aqueous dispersants

A process for making 1-alkyl-5-mercaptotetrazoles of the formula: ##STR1## wherein R is an alkyl group having 1 to 6 carbon atoms, comprising the steps of:

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Guilford, CT, United States of America

Ming Shen