National Institute of Radiological Sciences

Canon Medical Systems Corporation

Taisho Pharmaceutical Co., Ltd.

Nihon Nohyaku Co., Ltd.

National Institutes for Quantum Science and Technology

General Incorporated Association the Japan-multinational Trial Organization

Ming-Rong Zhang

Kazutoshi Suzuki

Atsuro Nakazato

Yasuo Sakurai

Tetsuya Suhara

Makoto Goto

Lin Xie

Masayuki Fujinaga

Masayuki Hanyu

Katsushi Kumata

Cheng-Long Huang

Masakazu Fukushima

Hiromi Wada

Shunsuke Fujiwara

An analysis apparatus according to an embodiment includes an extraction unit, a calculation unit, and an evaluation unit. The extraction unit extracts a detection value in a tumor region, a blood region, and a muscle region from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor. The calculation unit calculates a first comparison value that is a comparison result between the detection value in the blood region and the detection value in the tumor region, and a second comparison value that is a comparison result between the detection value in the muscle region and the detection value in the tumor region. The evaluation unit evaluates an accumulation of the drug in the tumor, based on the first comparison value and the second comparison value calculated by the calculation unit.

Analysis apparatus and analysis program

A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, aF-labeled ligand having various functional groups and a [F] fluorobenzene ring is synthesized by reacting the resulting diphenyliodonium salt with [F]F.

[object Object]

A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1):wherein Xand Xare same or different and each is hydrogen atom or halogen atom; Rand Rare same or different and each is hydrogen atom, an alkyl group having 1 to 10 carbon(s) or a halogen-substituted alkyl group having 1 to 10 carbon(s); and Ris a halogen-substituted alkyl group having 1 to 5 carbon(s), or a radioisotope thereof.

Phenyloxyaniline derivatives

Growing community of inventors

Chiba, Japan

Ming-Rong Zhang