Zhejiang Sanhua Commercial Refrigeration Controls Co., Ltd.

Sumgen Mab (beijing) Biotech Co., Ltd.

Hangzhou Sumgen Biotech Co., Ltd.

Zhejiang Sanhua Co., Ltd

Zhejiang Sanhua Climate and Appliance Controls Group Co., Ltd.

Sumgen Mab Biotech Co., Ltd.

Ming Lv

Xiaoran Ding

Bin Tan

Xuegong Wang

Shiwei Miao

Damai Yang

Jiancheng Zhi

Baijiang Qian

Jiangcheng Zhi

Yuzhong Chen

An electric valve includes a valve seat component, and a valve core component. The valve seat component includes a valve seat and a sealing ring. The valve core component includes a valve core. The valve core includes a lower section, and the lower section is annular. The valve seat component further includes an inner bushing and a pressure block. The valve seat includes an axial through hole, and at least part of the inner bushing is arranged in the axial through hole. The sealing ring is arranged between an outer side of the inner bushing and the valve seat. The valve seat includes a first stepped portion, and a lower end surface of the pressure block is abutted against the first stepped portion and/or the sealing ring.

Electric valve

Provided is a fusion protein, comprising a first binding domain that specifically binds a tumor-associated antigen, and a second binding domain that specifically binds a CD47 protein, wherein the second binding domain comprises a mutant of a human SIRPα variant 1. Also provided are an immunoconjugate, nucleic acid molecules, vectors, compositions, and cells related to the fusion protein and preparation methods therefor, and the uses thereof in the preparation of medicaments.

Fusion protein and use thereof

An electric valve includes a valve body component, a valve seat component, and a valve core component. The valve core component comprises a valve core. The valve core includes a body portion and a lower section, and the lower section is annular. A transition portion is included between the body portion and the lower section. The transition portion includes a first transition section connected with the lower section. An outer diameter of an upper end of the first transition section is greater than an outer diameter of a lower end of the first transition section.

An electric valve includes a valve seat component, a valve body component, and a valve core component. The valve core component includes a sealing portion. The valve core component is arranged in a valve chamber of the electric valve, and the valve core component includes a valve core body. The valve core body is substantially tubular, the valve core body has an integral structure, and the valve core body includes an annular thin-walled portion to abut against the sealing portion of the valve seat component. The thickness of the annular thin-walled portion is M, and 0.3 mm≤M≤2.0 mm.

A valve core assembly includes a transmission component and a valve core component. The valve core component includes a valve core body and a lower stop component, and the valve core body is substantially tubular. The lower stop component is provided in an inner chamber of the valve core body and is fixedly connected to the valve core body. The lower stop component includes a lower stop portion. An upper chamber is located above the lower stop portion, and a lower chamber is located below the lower stop portion. The lower stop component includes a first axial through hole communicating with the upper chamber and the lower chamber.

Valve core assembly

Provided is an antibody or an antigen-binding fragment thereof, having one or more properties selected from the group consisting of: 1) being capable of binding to an AXL protein by a Kvalue of 1×10M or lower; 2) being capable of specifically recognizing an AXL protein expressed on a cell surface; and 3) being capable of mediating internalization after binding to the AXL protein expressed on the cell surface. The antibody may further used for constructing an immunoconjugate. The antibody and the immunoconjugate may inhibit the proliferation of tumor cells.

Antibody binding to AXL protein and application thereof

Provided by the present invention are a fusion protein binding to a CD47 protein and an application thereof, wherein the fusion protein is capable of binding to a CD47 protein by using a KD value of 1×10M or lower. The fusion protein may specifically block the interaction between a CD47 protein and SIRPα without causing a blood coagulation reaction, and may further inhibit the growth and/or proliferation of tumors or tumor cells.

Fusion protein binding to CD47 protein and application thereof

An electric valve, including a valve body part, a valve seat part, and a valve core part. The valve core part is provided in an inner cavity of the valve body part. The valve core part comprises a valve core. The valve core comprises a lower segment portion. The valve base part comprises a first sealing portion. An end of the lower segment portion can be abutted against or separated from the first sealing portion. The valve body part comprises a bushing part. The valve core part comprises a second sealing portion. The diameter Dof the axial projection loop of the outer edge of the second sealing portion on the cross section of the lower segment portion, the outer diameter Dof the lower segment portion, and the inner diameter Dof the lower segment portion, satisfy: 0.2 mm&#x2264;D*(D&#x2212;D)&#x2264;6 mm.

An electric valve and manufacturing method therefor, the electric valve including a valve body part, a valve seat part, a transmission part and a valve core part, wherein the valve core part includes a valve core body and a lower stop part; the valve core body is essentially tubular, and the valve core body is of an integrated structure and includes an annular thin wall portion; the lower stop part is arranged in an inner cavity of the valve core body, and the lower stop part comprises a lower stop portion; an upper cavity is present above the lower stop portion, a lower cavity is present below the lower stop portion, and the lower stop part includes a first axial through hole which is in communication with the upper cavity and the lower cavity.

Electric valve and manufacturing method therefor

Provided by the invention is an antibody or an antigen-binding fragment thereof, which binds to a CD38 protein at a Kvalue below 1&#xd7;10-M. The antibody or an antigen-binding fragment thereof has strong specific recognition and binding capabilities for CD38 protein, and may kill CD38+ cells by means of antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and/or apoptosis. Further provided by the present invention is an application of the antibody or antigen-binding fragment thereof in preventing and treating tumors.

Growing community of inventors

Zhejiang, China

Ming Lv