Mesoscale Technologies, Llc.

Meso Scale Technology Llp

Ming Lu

Jonathan K Leland

Mark T Martin

Alan B Fischer

Robert Hoch

Richard J Massey

Liwen Dong

Pam Liang

Fabian Jameison

Graphitic nanotubes, which include tubular fullerenes (commonly called 'buckytubes') and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

Graphitic nanotubes in luminescence assays

Graphitic nanotubes, which include tubular fullerenes (commonly called &ldquo;buckytubes&rdquo;) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

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Lanham, MD, United States of America

Ming Lu