The Code Corporation

Novartis Ag

University of Pennsylvania

Microscan Systems Incorporated

Other

Ming Lei

George A Powell

Ryan Wayne Hoobler

Mark Ashby

Steve Pierce

Garrett Russell

Jason J Lee

Andreas Loew

Jennifer Brogdon

Lu Huang

Li Zhou

Jimin Zhang

Na Li

Saar Gill

Marco Ruella

Barbara Brannetti

Boris Engels

Brian Walter Granda

David Jenkins

Carl H June

Phil Utykanski

Jennifer Bordeaux

Carla Guimaraes

Thai Tran

Naveen Kumar Dakappagari

Ju Young Kim

Elena Orlando

Hans Bitter

Steven Highfill

Regina M Young

Richard G Long

Anuj Sajit Shah

David P Bubnoski

Jonathan Edward Bosley

Seth Alexander Ettenberg

Feng Cong

Karen Vincent

Eric Alldredge

John E Agapakis

Juihsiang Ray Shih

Carla Patricia Pinto Guimaraes

Jeffrey C Snyder

Joerg-Thomas Rissmann

Jennifer Mary Bordeaux

The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

CD20 therapies, CD22 therapies, and combination therapies with a CD19 chimeric antigen receptor (CAR)-expressing cell

A barcode reading application for a general-purpose computing device includes a motion detection module in addition to a decoding module. The motion detection module is configured to process image frames captured by a camera of the computing device for the purpose of performing motion detection. The barcode reading application can be configured so that the decoding module does not process captured image frames until motion has been detected in the camera's field of view. Because fewer processing resources are required for motion detection than for barcode reading, including motion detection capability in the barcode reading application can reduce processor usage in the computing device compared to a scenario where the decoding module is constantly processing captured image frames. Advantageously, however this reduction in processor usage can be achieved without reducing responsiveness of the barcode reading application, because the barcode reading application can still remain running between successive read attempts.

Barcode-reading application that is designed for a general-purpose computing device and that includes a motion detection module

The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.

Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain

Method of treating cancer by administering immune effector cells expressing a chimeric antigen receptor comprising a CD20 binding domain

Data can be collected from a plurality of barcode-reading devices associated with an enterprise. The collected data can be distinct from the decoded data that is generated by the barcode-reading devices when barcodes are read. For example, the collected data can include device data describing one or more characteristics of the barcode-reading device. Other types of data (e.g., camera data, license data, decoding metadata) can also be collected. The collected data can be sent to a remote server for processing and analysis. The remote server can provide feedback to the enterprise based on the results of analyzing the collected data.

Data collection for barcode-reading devices

Disclosed herein is a barcode reading system that includes an image decoding system, a communication interface, and an image sensor system package. The image decoding system may include a processor, memory, and a decoder stored in the memory. The image sensor system package may be coupled to the image decoding system via the communication interface. The image sensor system package may include a photo sensor array and pre-processing circuitry. The photo sensor array may be configured to capture image frames at a first speed. The pre-processing circuitry may be configured to perform one or more operations on the image frames captured by the photo sensor array. The pre-processing circuitry may be additionally configured to effect transfer of at least some of the image frames to the image decoding system via the communication interface at a second speed. The first speed may be greater than the second speed.

Architecture for faster decoding in a barcode reading system that includes a slow interface between the camera and decoder

A barcode reading application includes an image capture function for controlling a white light source and a camera of a mobile device to capture an image of a barcode in a target area. The barcode reading application also includes a decoder function for receiving the image of the barcode and generating decoded data representing data encoded in the barcode. The barcode reading application also includes a non-legacy mobile client function for transmitting the decoded data to a non-legacy system. The barcode reading application also includes a legacy mobile client function for transmitting the decoded data to an intermediate server, which then provides the decoded data received from the legacy mobile client function to a legacy system. The barcode reading application also includes a relay function for determining whether the decoded data is intended for the legacy system or the non-legacy system.

Barcode reading system having a legacy mobile client function, a non-legacy mobile client function, and a relay function

A system in accordance with the present disclosure may include a plurality of electronic devices that do not have Internet connectivity. Each electronic device may include a barcode decoder and a license activation application. The system may also include a computing device that has an Internet connection. The computing device may include a master program that is executable to obtain a plurality of identifiers from the plurality of electronic devices. The master program may also be executable to send at least one license request to a license server via the Internet connection. The at least one license request may include the plurality of identifiers. The master program may also be executable to receive a plurality of licenses from the license server in response to the at least one license request. The master program may also be executable to provide the plurality of licenses to the plurality of electronic devices.

Offline license activation for barcode decoders

Disclosed herein is an attachment for a smartphone. The smartphone may include i) a camera with an image sensor and a focusing lens located on a back side of the smartphone for capturing an image of a target area; and ii) a white light source on the back side of the smartphone. The attachment may include a targeting optic system. When the attachment is secured to the back side of the smartphone, the targeting optic system may receive illumination emitted by the white light source and direct the illumination towards the target area from a location that is not directly in front of the camera's image sensor. The location may be farther from the focusing lens than the white light source when measured parallel to the back side of the smartphone. The attachment may also direct the illumination into the target area via the targeting optic system.

Attachment including a targeting optic system that directs illumination from a white light source towards a target area

An application on a mobile device may include a barcode decoder. The application may be configured to download a configuration file. The configuration file may include an enterprise identifier that is uniquely associated with an enterprise. The application may additionally be configured to obtain a license key for the barcode decoder. The license key may be based on the enterprise identifier. The application may additionally be configured to transition the barcode decoder from an inactive state to an active state conditional upon verifying that the license key is based on the enterprise identifier.

Enterprise-level licensing for a barcode decoder within a mobile device application

A barcode reader may include barcode reading hardware, which may include an image sensor. The image sensor may capture an image of a barcode within a field of view. The barcode reading hardware may also include a communication interface for output of decoded data to a remote computing system. The barcode reader may also include volatile memory and non-volatile memory. The non-volatile memory may include start-up instructions. The barcode reader may also include a processor. The processor may be configured to, upon power-up of the barcode reader, execute the start-up instructions to obtain firmware for operating the barcode reader from a remote configuration server, load the firmware to the volatile memory, and commence execution of the firmware to commence barcode reading functions of the barcode reader without performing a re-boot operation.

Host device for obtaining operating instructions for a barcode reader from a remote server

This disclosure concerns a barcode reading system that includes a barcode reader and a data manipulation module. The barcode reader reads a barcode, decodes the barcode, and generates decoded data. The data manipulation module includes a data validation module and a data formatting module. The data validation module can perform one or more data validation operations on the decoded data. The data formatting module is separate from the data validation module. The data formatting module can perform one or more data formatting operations on either an output of the data validation module or on the decoded data. The output of the data validation module may include one or more data validation modifications. The barcode reading system may also include a host computer that is in electronic communication with the barcode reader. In some configurations, the barcode reader may include the data manipulation module. In other configurations, the host computer may include the data manipulation.

Barcode-scanning system configured for both data validation and data formatting

This disclosure describes methods and systems for using a barcode reader to read multiple barcodes positioned on an object. The barcode reader attempts to locate a first priority barcode within an image using first priority information. The priority information may define a region of interest within the image. The barcode reader may search only the region of interest for the first priority barcode. The priority information may define one or more characteristics of the first priority barcode. Based on the results of attempting to locate the first priority barcode, the barcode reader determines whether to attempt to locate a second priority barcode within the image. The barcode reader may discard the image if the barcode reader fails to locate the first priority barcode or the results of attempting to locate the first priority barcode indicate that the image is unlikely to contain a decodable second priority barcode.

Efficiency when reading multiple barcodes on objects

Growing community of inventors

Princeton Junction, NJ, United States of America

Ming Lei