Unitech Pharmaceuticals, Inc.

National Defense Medical Center

National Defense University

Ming-Kuan Hu

Jiajiu Shaw

Yung-Feng Liao

Kuo-Hui Wu

Wen-Po Lin

Fu-Chu Yang

The invention provides a type of novel 1,2,3,4-tetrahydroisoquinoline derivatives with a structure of formula (I): wherein R1 represents propargyl or cyclopropylmethyl; wherein R2 represents N-ethyl-N-methylamino, 1-Pyrrolidyl, 1-Piperidinyl, or 1-Morpholinyl. The invention provides further a process for preparing said derivatives and a pharmaceutical composition containing the same. Said derivatives can be used to modulate the proteolytic process of amyloid precursor proteins (APP), and provides further novel compounds useful for treating Alzheimer's disease (AD).

1,2,3,4-tetrahydroisoquinoline derivatives, preparation process therefor and pharmaceutical composition containing the same

The BC powders (particle size&#x3c;10 &#x3bc;m, Taiwan Paiho) are activated with surfactant sodium alginate under stirred for 1 h. The as-prepared BC powders (2 g) are immersed into 100 mL of biamminesilver nitrate ([Ag(NH)]NO) solutions, which are formed by adding 28 wt. % aqueous ammonia into AgNOsolution at room temperature. After stirring for 1 h, dilute aqueous solutions of hydrazine monohydrate are separately prepared and introduced to the BC-AgNOsolutions in appropriate quantities (molar ratio 1:1 with respect to silver nitrate) by a syringe. Stirring is continued under inert atmosphere at room temperature for another 4 h. The BC/Ag particles are separated and washed with deionized water and ethanol, then dried in vacuum at 60&#xb0; C. for overnight.

Manufacturing method of bamboo charcoal supporting silver and products thereof

A series of tacrine derivatives has be synthesized and disclosed. These tacrine derivatives were claimed to be new and be useful for the treatment of Alzheimer's disease alone or in combination with other drugs for Alzheimer's disease. These tacrine derivatives may be formulated into suitable pharmaceutical dosage forms for the treatment of Alzheimer's disease.

Tacrine derivatives for treating Alzheimer's disease

A series of N-benzoyl-.alpha.-alkylated azatyrosines has been synthesized and disclosed. Their in-vitro activities were positive against several human cancer cell lines and significantly more effective than L-azatyrosine. These azatyrosine derivatives were claimed to be new and be useful as anticancer agents alone or in combination with other anticancer agents. These azatyrosine derivatives may be formulated into suitable pharmaceutical dosage forms for the treatment of cancer.

Growing community of inventors

Taipei, Taiwan

Ming-Kuan Hu