Food Industry Research and Development Institute

Other

Ming-Jen Cheng

Yen-Lin Chen

Gwo-Fang Yuan

Kai-Ping Chen

Ming-Der Wu

Shie-Jea Lin

Hui-Ping Chen

Ping-Hsun Yang

Hsuen-Chun Liao

Ta-Wei Liu

Yu-Shan Lin

Chi-Hua Chen

Shiow-Wen Chen

Wen-Jung Wu

Ping-Shin Yang

The present invention relates to a monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPAR&#x3b3; and/or C/EBP&#x3b1;, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

Monascuspurpurones, preparation and uses thereof

The present invention relates to a novel monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPAR&#x3b3; and/or C/EBP&#x3b1;, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

Monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones

The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPAR&#x3b3;, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.

Pyridine alkaloids, preparation process thereof, and the uses of the pyridine alkaloids

The present invention concerns the uses of an azaphilone compound of formula (I): formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.

Use of azaphilone compounds for the modulation of the activity of a nuclear hormone receptor

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Hsinchu, Taiwan

Ming-Jen Cheng