Ascentage Pharma (suzhou) Co., Ltd.

Ascentage Pharma Group Corp Limited

Realtek Semiconductor Inc.

Guangzhou Healthquest Pharma Co., Ltd.

Ascentage Pharma Goup Corp Limited

Ascentage Pharma Co., Ltd.

Ming Guo

Jianfeng Wen

Tianzhu Wu

Jianpeng Feng

Huirong Lu

Feng Xu

Jing Zhang

Yanqiong Lin

Ming Jin

Qianlei Cao

Zhenzhong Shao

Pengfei Cao

Shangjun Teng

Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof. In particular, the present invention discloses a process for preparing a compound of formula 6 as shown in below and a pharmaceutical composition comprising a compound of formula 6 for treating cancer,

Process for preparing alkynyl-containing compound and intermediate thereof

The present invention relates to a pharmaceutical composition comprising a sulfonamide as an inhibitor of Bcl-2/Bcl-xL, especially compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoromethyl sulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester or a pharmaceutically acceptable salt thereof and suitable excipients, preferably a pharmaceutical composition in the form of a lyophilized powder. The invention also relates to a method for preparing the pharmaceutical composition.

Pharmaceutical composition and preparation method thereof

Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.

Method for preparing 2-indolinospirone compound and intermediate thereof

The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.

Method for preparing sulfonamides drugs

The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Process for preparing sulfonamide compounds

A packet detecting method includes receiving the wireless signal, generating a local characteristic sequence, acquiring a first cross-correlation result between the wireless signal and the local characteristic sequence, determining if a packet format of the wireless signal is a target packet format according to the first correlation result, generating at least one interference characteristic sequence according to the local characteristic sequence, a signal sampling frequency, and at least one working frequency difference, acquiring a second cross-correlation result between the wireless signal and the at least one interference characteristic sequence, and detecting a center frequency of the wireless signal for determining if a packet of the wireless signal is transmitted through a target channel according to the first correlation result and the second correlation result. The at least one interference characteristic sequence corresponds to at least one interference frequency.

Packet detecting method of a wireless signal and packet detecting system of the wireless signal capable of identifying adjacent channel interference

Growing community of inventors

Suzhou, China

Ming Guo