Koninklijke Philips Corporation N.v.

Yale University

Ming De Lin

Michael Grass

Ewald Roessl

Tobias Klinder

Dirk Schaefer

Eberhard Sebastian Hansis

Christian Haase

Carsten Oliver Schirra

James S Duncan

John Treilhard

Susanne Smolka

Jean-François Geschwind

In an image guidance method, a stream of cone-beam computed tomography (CBCT) images of an anatomical organ is acquired using a CBCT imaging device (). For each CBCT image (), the surface of the organ in the CBCT image is segmented to generate a segmented surface () of the anatomical organ in the CBCT image. Occluded shape reconstruction () using a statistical shape prior () may be used to reconstruct a missing or occluded surface portion. A pre-operative medical image () of the anatomical organ and the CBCT image are spatially registered by warping one of the images to the other of the images using point set registration of a segmented surface () of the organ in the preoperative medical image and the segmented surface of the organ in the CBCT image. A fused image () is displayed that combines the warped image and the other image.

CBCT to MR registration via occluded shape reconstruction and robust point matching

The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

Drug concentration determination after transarterial chemoembolization with different sized drug-eluting microsphere beads

An imaging system () includes a radiation source () that emits radiation that traverses an examination region and imageable drug eluting beads in tissue of interest located therein, a spectral detector array () detects radiation traversing the examination region and generates a signal indicative thereof, spectral processing circuitry () that spectrally resolves the signal based on a plurality of thresholds (), and a reconstructor () that generates spectral volumetric image data corresponding the imageable drug eluting beads based on the spectrally resolved signal.

Spectral CT visualization of imageable drug eluting beads

Growing community of inventors

New Haven, CT, United States of America

Ming De Lin