Banyan Biomarkers, Inc.

University of Florida Research Foundation Inc

US Government as Represented by the Secretary of the Army

Ming-Cheng Liu

Monika Oli

Kevin Ka-Wang Wang

Ka-Wang (Kevin) Wang

Zhiqun Zhang

Ronald L Hayes

Jitendra Ramanlal Dave

The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

Neural proteins as biomarkers for nervous system injury and other neural disorders

Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, Alzeimer's disease, Parkinson disease and Chronic Traumatic Encephalopathy (CTE). The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or CSF. Such biomarkers include Tau and GFAP proteins, their proteolytic breakdown products, brain specific or enriched micro-RNA, and brain specific or enriched protein directed autoantibodies. The processes and materials are operable to detect the presence of absence of acute, subacute or chronic brain injuries and predict outcome for the brain injury.

Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury

The present invention identities biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

Growing community of inventors

Gainesville, FL, United States of America

Ming-Cheng Liu