University of California

Ming Chen Hammond

Russell E Vance

Alexander J Westermann

Stephen C Wilson

Elie J Diner

Qian Qin

Dara Burdette

Methods and compositions are provided for increasing the production of a type I interferon (IFN) in a cell. Aspects of the methods include increasing the level of a 2′-5′ phosphodiester linkage comprising cyclic-di-nucleotide in a cell in a manner sufficient to increase production of the type I interferon (IFN) by the cell. Also provided are compositions and kits for practicing the embodiments of the methods.

Cyclic di-nucleotide induction of type I interferon

The present disclosure relates to inducible hybrid plant 5S rRNA mimic (P5SM) RNA elements that regulate gene expression by alternative splicing, and to methods of using such RNA elements for regulating transgene expression in eukaryotic host cells and plants.

P5SM suicide exon for regulating gene expression

Growing community of inventors

Berkeley, CA, United States of America

Ming Chen Hammond