Bayspec, Inc.

Biospex, Inc.

Ming Chai

Wei Yang

Shu Zhang

Charlie Zhang

Changqing Wang

William Escobar

Krisztian Gabor Torma

Xiaoguang Wu

Wei Yang Terziyan

Nam Duc Lai

Masayuki Kamata

Leyun Zhu

Yongqiang Qiu

William (Wei) Yang

Chad Lieber

William Yang

Miao Yang

Doneil Hoekman

Chase Wang

Patrick Yang

Techniques and systems for multi-modal ionization for mass spectrometry are provided. In some embodiments, a method may comprise: receiving an analyte; ionizing some molecules of the analyte using a first ionization method to produce first ions; ionizing other molecules of the analyte using a second ionization method to produce second ions; and providing the first and second ions to a mass analyzer.

Multi-modal ionization for mass spectrometry

Methods and systems for spectroscopy are provided. Exemplary methods include: illuminating, with a tunable laser, an analyte with first light; detecting, with a filtered sensor, a first Raman signal; illuminating, with the tunable laser, the analyte using second light; detecting, with the filtered sensor, a second Raman signal, the second Raman signal being shifted from the first Raman signal by a second predetermined increment; illuminating, with the tunable laser, the analyte using third light; detecting, with the filtered sensor, a third Raman signal, the third Raman signal being shifted from the second Raman signal by the second predetermined increment; constructing a Raman spectrum using the first Raman signal, the second Raman signal, and the third Raman signal; and determining at least one molecule of the analyte using the Raman spectrum and a database of predetermined Raman spectra.

Wearable spectroscopy using filtered sensor

Systems for spectroscopy are provided. Exemplary systems include: an enclosure; a tunable laser disposed in the enclosure; an opening on a surface of the enclosure; a beam splitter disposed in the enclosure, the beam splitter being optically coupled to the tunable laser and the opening; a sensor, a sensing surface of the sensor having a filter disposed thereon; and electronics coupled to the tunable laser and the sensor, the electronics including a processor, memory, and a battery.

Wearable spectrometer with filtered sensor

Systems and methods for hybrid time-resolved and time-shifted spectroscopy for measuring biological analytes are disclosed. Exemplary methods include: illuminating an analyte using first light from and excitation source, the first light having a first excitation wavelength; detecting a first spectrum from the analyte illuminated by the first light using a time-resolved spectroscopy technique, the first spectrum including a first Raman signal and fluorescence; illuminating the analyte using second light, the second light having a second excitation wavelength; detecting a second spectrum using a time-resolved spectroscopy technique; illuminating the analyte using third light, the third light having a third excitation wavelength; detecting a third spectrum; recovering the first Raman signal using the first spectrum, the second spectrum, and the third spectrum using an inverse transform; and using the first Raman signal to identify and measure at least one molecule of the analyte using a database of identified Raman signals.

Hybrid time-resolved and time-shifted spectroscopy for measuring biological analytes

Systems and methods for time-resolved spectroscopy. Exemplary methods include: providing first, second, and third light using an excitation source; receiving first scattered light from a material responsive to the providing the first light; signaling the detector, after a delay, to provide a first spectrum of the received first scattered light; receiving second scattered light from the material responsive to the providing the second light; signaling the detector, after the delay, to provide a second spectrum of the received second scattered light; receiving third scattered light from the material responsive to the providing the third light; signaling the detector, after the delay, to provide a third spectrum of the received third scattered light; recovering a spectrum of the material using the first spectrum, second spectrum, and third spectrum; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

Measuring biological analytes using time-resolved spectroscopy

Raman spectrometers are provided that illuminate a sample with two or more different beams of light, each characterized by a different primary frequency. Scattered light from the sample is separated into multiple Raman spectra, one for each primary frequency. The multiple Raman spectra can be evaluated individually, or they can be added together to form a composite spectrum that is then evaluated.

Raman spectroscopy using multiple excitation wavelengths

A portable or handheld mass spectrometer making use of a cryogenic pumping, ion pumping or getter pumping system. The portable mass spectrometer contains a cryopump, ion pump, or getter pump, and operates in conjunction with a fixed docking station. The docking station contains a backing pump to bring the mass spectrometer manifold down to operating pressure prior to being placed into portable operation using the cryopump, ion pump, or getter pump. The individual pumps may be operated either separately or simultaneously. This configuration permits the portable mass spectrometer module to be small, lightweight and rugged, and yet be easily and quickly recharged and regenerated for use in either a field or laboratory environment.

Apparatus and methods for creating a vacuum in a portable mass spectrometer

A spectrograph having multiple excitation wavelength ranges is disclosed. The spectrograph can include a wavelength switching mechanism to switch between different wavelength ranges in accordance with the wavelength of an incoming light signal. The wavelength switching mechanism can include multiple optical assemblies (or elements) corresponding to the different wavelength ranges for processing the incoming light signal. The mechanism can also include a switching component for switching the optical assemblies to align the appropriate assembly with the incoming light signal. Each optical assembly can include one or more transmission gratings to disperse the incoming light signal into multiple wavelengths within a particular wavelength range and a reflecting mirror proximate to the grating(s) to reflect the wavelengths of light back through the grating(s) to photodetectors for measuring to wavelengths to generate a light spectrum. The spectrograph can be used in Raman spectroscopy.

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Union City, CA, United States of America

Ming Chai