Intel Corporation

Hewlett-Packard Development Company, L.p.

Mineo Yamakawa

Andrew A Berlin

Selena Chan

Xing Su

Valluri Ramana Rao

Tae-Woong T Koo

Qing Ma

Narayanan Sundararajan

Zhiyong Li

Li-Peng Wang

Yuegang Zhang

Narayan Sundararajan

Gabi Neubauer

Kenneth B Swartz

David J Liu

Kai Wu

Steven J Kirch

Gary A Gibson

John Heck

Steven J Barcelo

Ansoon Kim

Shih-Yuan Wang

Alexandre M Bratkovski

Eric Cabot Hannah

Charles Santori

James William Stasiak

Huei Pei Kuo

Richard O Jones

Anita Rogacs

Kenneth Ward

Horst Haussecker

Lei B Sun

Francesco Aieta

Jingwu Zhang

Sunghoon Kwon

Liming Wang

David Eric Schwartz

Zhang-Lin Zhou

Val M Dubin

Kenneth Schwartz

Tac-Woong Koo

Steve Kirch

Joseph V Kosmoski

Deane C Little

Zhang Jingwu

Optical readers are disclosed in examples herein. An example optical reader including a light source to emit a light beam; and a spot pattern generator to receive the light beam and to generate a two-dimensional spot array from the light beam, the two-dimensional spot array to be directed toward a substrate having nanostructures, the two-dimensional spot array to be sensed to detect a presence or an absence of a substance of interest on the substrate.

Optical readers

A system includes an illumination source, a detector and a processor. The detector acquires spectral measurements of a sample under test under at least one varying condition. The processor processes the measurements to generate at least one spectral representation that includes Raman spectra and at least one spectral representation that includes non-Raman spectra.

Multiple spectral measurement acquisition apparatus and the methods of using same

The present disclosure is drawn to a device for monitoring and controlling live cells and associated methods. In an example, the device can include a plurality of elongated nanostructures affixed to a substrate. The elongated nanostructures can each have an attachment end and a free end opposite the attachment end. The free end includes a metal and the attachment end is affixed to the substrate. The device can further include a functionalization layer that is coated on the free end of at least a portion of the plurality of elongated nanostructures. The functionalization layer can be formulated to retain live cells, and the device can be configured to be used in conjunction with a detector, such as a Raman spectrometer, in order to monitor growth of live cells.

Method for monitoring and controlling cellular growth

An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

Device and method for particle complex handling

According to an example, an apparatus for performing spectroscopy includes an elongated substrate having a shape and size to be inserted into a specimen, wherein the elongated substrate has a first end and a second end. The apparatus also includes a plurality of surface-enhanced spectroscopy (SES) elements positioned on an exterior surface of the elongated substrate at a location between the first end and the second end of the elongated substrate.

Apparatus having surface-enhanced spectroscopy elements on an exterior surface

Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.

Biosensor utilizing a resonator having a functionalized surface

The present invention is directed to methods, for example phage display assays, for bioengineering peptides that bind to individual distinct nucleotides. Also provided are peptides engineered by such methods. Specifically, cyclic peptides that bind individual distinct nucleotides are provided herein.

Methods for isolating a peptide methods for identifying a peptide

Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction cavities containing sensors to monitor changes in solutions contained in the reaction cavities. Additional embodiments provide devices and methods for sequencing DNA using arrays of reaction cavities that allow for optical monitoring of solutions in the reaction cavities. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced.

Sensor arrays and nucleic acid sequencing applications

In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy. Parameters may be estimated from the plurality of images, using one or more models of known molecular structures to provide a model-based analysis. The estimated parameters may be fused, with further input from physical models of known molecular structures. The fused parameters may be used to characterize the subjects. Such characterization may include the detection and/or identification of specific molecular structures, such as proteins, peptides and/or nucleic acids of known sequence and/or structure. In some embodiments of the invention the structural characterizations may be used to identify previously unknown properties of a subject molecule.

Model-based fusion of scanning probe microscopic images for detection and identification of molecular structures

A strain gauge or other device may include a deformable medium and discrete plasmon supporting structures arranged to create one or more plasmon resonances that change with deformation of the medium and provide the device with an optical characteristic that indicates the deformation of the medium.

Plasmon resonance based strain gauge

Scattering spectroscopy employs a scattering spectroscopy enhancing structure having a hotspot on a first side of a substrate and a nanopore in the substrate, where the nanopore is aligned with the hotspot.

Scattering spectroscopy employing hotspot-aligned nanopores

Microfluidic apparatus including integrated porous substrate/sensors that may be used for detecting targeted biological and chemical molecules and compounds. In one aspect, upper and lower microfluidic channels are defined in respective halves of a substrate, which are sandwiched around a porous membrane upon assembly. In other aspect, the upper and lower channels are formed such that a portion of the lower channel passes beneath a portion of the upper channel to form a cross-channel area, wherein the membrane is disposed between the two channels. In various embodiments, one or more porous membranes are disposed proximate to corresponding cross-channel areas defined by one or more upper and lower channels. The porous membrane may also have sensing characteristics, such that it produces a change in an optical and/or electronic characteristic. Accordingly, the apparatus may further include instrumentation or detection equipment to measure the changes, such as optic-based detectors and electronic instrumentation.

Microfluidic apparatus with integrated porous-substrate/sensor for real-time (BIO) chemical molecule detection

Growing community of inventors

Campbell, CA, United States of America

Mineo Yamakawa