Seiko Instruments Inc

Seiko Instruments R & D Center Inc.

Minao Yamamoto

Masataka Shinogi

Takahiko Nakamura

Hiroyuki Muramatsu

Yoshifumi Yoshida

Matsuo Kishi

Takashi Nakamura

Hiroshi Muramatsu

Yoko Shinohara

Haruki Kato

A reactor comprises a main body having a flow path substrate and a crystal substrate chemically bonded to the flow path substrate to form a flow path for running a sample to be measured and a reactor tank connected to the flow path. An adsorption film is disposed in the reactor tank for adsorbing a specific substance contained in the sample to be measured. A measuring device measures a physical quantity of the specific substance contained in the sample and adsorbed by the adsorption film.

Reactor, micro-reactor chip, micro-reactor system, and method for manufacturing the reactor

A blood rheology measuring apparatus has a measuring portion for measuring a flow velocity of the blood flowing in a blood vessel of a person in a mode of a Doppler shift signal by transmitting and receiving a wave to and from a surface of the person's skin. An information processing portion calculates an intensity at each of frequency components of the Doppler shift signal, extracts a maximum frequency in a signal at an intensity level equal to or larger than a threshold in the histogram or a maximum frequency when an integrated value from a low frequency component reaches a predetermined rate of a total thereof in the histogram, and provides a temporal change waveform of the extracted frequency. The blood rheology is analyzed by an area value of a portion at and above a line connecting a minimum value of one pulse waveform and a minimum value of a successive pulse waveform of the frequency waveform.

Blood rheology measuring apparatus

A blood rheology measuring apparatus has a measuring portion for measuring a flow velocity of the blood flowing in a blood vessel of a person in a mode of a Doppler shift signal by transmitting and receiving a wave to and from a surface of the person's skin. An information processing portion calculates an intensity at each of frequency components of the Doppler shift signal, extracts a maximum frequency in a signal at an intensity level equal to or larger than a threshold in the histogram or a maximum frequency when an integrated value from a low frequency component reaches a predetermined rate of a total thereof in the histogram, and provides a temporal change waveform of the extracted frequency. The blood rheology is analyzed based on the maximum frequency in the frequency waveform.

A microchip has a substrate on which there are formed a reaction bath section, a first flow channel to which are connected a supply channel that supplies a buffer solution and the reaction bath section, a second flow channel to which are connected a supply channel that supplies a sample solution containing a first substance and a channel that discharges the sample and buffer solutions to an exterior of the substrate, and a connecting channel connecting the first flow channel to the second flow channel. The reaction bath section receives the first and second substances so that the first and second substances react in the reaction bath section. The first and second flow channels are provided with valves disposed relative to the connecting channel such that selective opening and closing of the valves causes the buffer solution to flow first into the reaction bath section at a preselected speed and the sample solution to flow second into the reaction bath section at the preselected speed to cause the first and second substances to react in the reaction bath section.

Microchip for analysis, analysis system having the same, and analysis method

In a method of calculating circulation dynamics of a living body, a resistance component corresponding to a shape of a blood vessel in the living body is derived using previously obtained values of viscosity, pressure and flow rate of blood flowing in the blood vessel. Information corresponding to the viscosity of the blood is calculated using the derived resistance component.

Method of calculating circulation dynamics of a living body

A blood rheology measuring apparatus has a measuring portion for measuring blood circulation information inside of a living body from outside of the living body. The blood circulation information is a maximum blood flow velocity for one pulse. An information processing portion processes the measured information from the measuring portion to obtain information concerning a blood rheology of the living body.

A cooling unit is structured such that a temperature sensor is formed on at least one of the substrates that form a thermoelectric conversion device to which thermoelectric elements are connected, an input/output electrode extending from the temperature sensor and an electrode formed on the other surface opposed to the substrate on which the temperature sensor is formed are connected to each other by electrically conductive material, and a control circuit for controlling a current supplied to the thermoelectric conversion device according to an output of the temperature sensor is connected thereto. By this structure, only one surface of the substrate is subjected to a manufacturing process, and there is no need for a temperature sensor such as a thermistor to be supplied as a discrete component for mounting on a substrate of the thermoelectric conversion device. There is also no need for a temperature sensor to be connected directly on a surface of the thermoelectric conversion device which is to be adjusted in temperature, thereby being capable of easily and accurately adjusting the temperature at the thermoelectric conversion device.

Cooling unit

A .pi.-type thermoelectric conversion component detects and controls temperature and at the same time exhibits a cooling performance inherently possessed by the thermoelectric conversion component without the need for mounting a discrete temperature detecting unit. To achieve this, a temperature detecting unit, such as a thin film thermistor or doped semiconductor region, is directly integrated on a surface of a substrate forming the thermoelectric component. In one embodiment, a monocrystalline silicon wafer is used as at least one of the opposing substrates of the thermoelectric conversion component, a temperature detecting unit having a diffused resistor is formed therein. An electrode of the temperature detecting unit is connected to an electrode formed on the opposing substrate to reduce the thermal load. There is thus no need for mounting a discrete temperature detecting unit, which places a thermal load on the thermoelectric conversion component, and it is thus possible to perform temperature detection from the same substrate to which a power supply of the thermoelectric conversion component is applied. It is also possible to obtain a cooling performance inherently possessed by the thermoelectric conversion component without the need to increase the performance criteria of the device to incorporate a temperature detecting unit.

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Chiba, Japan

Minao Yamamoto