Tao Health Life Pharma Co., Ltd.

Minako Hoshi

Michio Sato

Koji Naito

Satoshi Horie

Munehiro Noda

Shoji Ideno

Hajime Horii

In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na/K-ATPase &#x3b1;3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na/K-ATPase &#x3b1;3, and the like.

Neurotoxic target for amylospheroid, method and material for reducing the neurotoxicity of amylospheroid, and use thereof

Provided is a method for producing synthetic amylospheroids efficiently, the method including agitating a liquid containing amyloid &#x3b2;-peptides in the presence of a plasticizer. Amylospheroid refers to an assembly of amyloid &#x3b2;-peptides that selectively can induce cell death of functionally mature neurons. Amylospheroid is considered to play a central role in the development of Alzheimer's disease and dementia with Lewy bodies.

Method for producing synthetic amylospheroid

An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid &#x3b2; fibrils or monomeric amyloid &#x3b2;-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid &#x3b2; fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid &#x3b2;-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.

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Kyoto, Japan

Minako Hoshi