University of California

Arizona State University

Min Zhao

Lei Zhang

Junfeng Feng

Quan Qing

Houpu Li

John Albeck

Liang Guo

A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway.

Cell signaling pathway activation by local AC electric field

Systems and methods are provided for migrating cells implanted or endogenous in tissue. The system may include first and second delivery electrodes configured for insertion in tissue and a direct current (DC) power source operatively coupled to the first and second delivery electrodes. The system further may include a programmable controller operatively coupled to the DC power source, wherein the programmable controller is programmed to direct the DC power source to deliver an electric field between the first delivery electrode and the second delivery electrode at a stimulation to nonstimulation ratio sufficient to cause the cells to migrate within tissue selectively.

Systems and methods for selectively migrating cells using electric fields

Growing community of inventors

Davis, CA, United States of America

Min Zhao