Industrial Technology Research Institute

Min-Ying Lin

Maggie J M Lu

Chih-Peng Liu

Chia-Mu Tu

Shuen-Hsiang Chou

John Jianghann Lin

Hsiang-Fa Liang

Jui-Hsiang Chen

Tsan-Lin Hu

Ming-Cheng Wei

Felice Cheng

Jui-Mei Lu

Yi-Ju Ko

Hsiang-Wen Tseng

Ya-Chin Lo

Chun-Min Liu

Yi-Ting Hsieh

Yu-Wen Lo

Po-Hung Lai

Tse-Min Teng

Chia-Wen Huang

Chia-Wen Liu

Po Hong Lai

Chiao Pin Li

Sung En Chen

Yo Wen Lo

Ming-Thau Sheu

Yi-Man Chou

John Jiang Hann Lin

Sung En Cheng

The disclosure provides a recipe for in-situ gel, formed by dissolving at least one polymer and at least one gel prevention agent in a polar solvent to form a solution and placing the solution in a condition for in-situ forming gels. The disclosure also provides an implant and a drug delivery system formed by the recipe.

Recipe for in-situ gel, and implant, drug delivery system formed thereby

The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C-Calkane, wherein the modified histidine and the polymer or C-Calkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C-Calkane is about 0-40%.

Biomedical composition

The disclosure provides a pharmaceutical composition. The pharmaceutical composition includes a chitosan with palmitoyl groups and an active agent. According to another embodiment, the pharmaceutical composition can further include a gelling accelerating agent. According to an embodiment of the disclosure, the active agent of the disclosure can be administered in the form of a nano-drug, liposome, micelle, or microparticle.

Pharmaceutical composition

A sustained release composition comprising a polymer and manufacturing method thereof. The sustained release composition comprises a polymer, a bioactive agent, and a release rate determined agent, wherein the release rate determined agent is dispersed in the sustained release composition to control the release rate of the bioactive agent. The method comprises providing an oil phase comprising a bioactive agent, a polymer, and a release rate determined agent; providing an aqueous phase comprising a surfactant; mixing the oil phase with the aqueous phase to form the sustained release composition having a controlled release effect.

Sustained release composition and manufacturing method thereof

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Hsinchu, Taiwan

Min-Ying Lin