Cardax Pharmaceuticals, Inc.

Cardax Pharma, Inc.

Min Yang

Peng Cho Tang

William Bert Geiss

Henry Lee Jackson

Samuel Fournier Lockwood

Geoff Nadolski

Richard Williams

David C Burdick

Zhiqiang Fang

Yishu Du

Henry L Jackson

William Geiss

David Burdick

A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates

A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.

Methods for the synthesis of astaxanthin

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Vernon Hills, IL, United States of America

Min Yang