Abbott Point of Care Inc.

Siemens Medical Solutions Usa, Inc.

Siemens Aktiengesellschaft

Min Xie

Stephen C Wardlaw

Lining Yang

Zhizhou Wang

Qiang Cheng

Michael Pisot

Changhua Yu

David Herzog

Yiming Wu

Udeepta D Bordoloi

Smita Krishnan

Robert Schneider

Daqing Xue

Cord Mueller

Yang Zhang

Shaohong Wang

Gabriel Artaud

Anil Patil

Chong Chen

Chanhua Yu

An apparatus and a method for identifying at least one type of white blood cell (WBC) within a whole blood sample is provided. The method includes: adding at least one colorant to the sample; providing at least one fluorescent excitation light and at least one transmission light; receiving both light fluorescing from and transmitted through the sample and producing signals representative thereof; creating at least one image of the sample using the signals; identifying WBCs within the sample image; quantitatively analyzing at least some of the identified WBCs within the image, including determining one or more quantitative values; and identifying at least one type of WBC from the identified WBCs using the quantitative values.

Method and apparatus for automated whole blood sample analyses from microscopy images

A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

Method for imaging biologic fluid samples using a predetermined distribution

A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.

A method and apparatus for identifying platelets within a whole blood sample. The method includes the steps of: a) adding at least one colorant to the whole blood sample, which colorant is operable to tag platelets; b) disposing the blood sample into a chamber defined by at least one transparent panel; c) imaging at least a portion of the sample quiescently residing within the chamber to create one or more images; and d) identifying one or more platelets within the sample using an analyzer adapted to identify the platelets based on quantitatively determinable features within the image using a analyzer, which quantitatively determinable features include intensity differences.

Method and apparatus for automated platelet identification within a whole blood sample from microscopy images

A method and apparatus for analyzing white blood cells (WBCs) within a whole blood sample quiescently residing within a chamber is provided. The chamber is defined by at least one transparent panel, and the whole blood sample includes at least one colorant operable to differentially identify at least one WBC type from another WBC type within the sample. The method includes the steps of: a) creating at least one image of the sample quiescently residing within the chamber; b) identifying portions of the sample image, with each portion representing a single WBC; c) compressing the sample image portions using a first compression algorithm; and d) one of compressing a remainder of the sample image not included in the portions using a second compression algorithm, or discarding the remainder.

Method and apparatus for compressing imaging data of whole blood sample analyses

A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius.

Method and apparatus for determining mean cell volume of red blood cells

A method and apparatus for imaging a biologic fluid sample quiescently residing within a chamber is provided. The method includes the steps of: a) positioning the chamber at a Z-axis position relative to an objective lens having a lens axis, wherein the Z-axis is parallel to the lens axis; b) moving one or both of the chamber and the objective lens relative to one another at a velocity along the Z-axis; and c) creating one or more images of the biologic fluid sample as one or both of the chamber and the objective lens are moving at a velocity relative to one another within a focus search range along the Z-axis.

Method and apparatus for fast focus imaging biologic specimens

A system and method for rendering images, and performing operations such as windowing and leveling, when the parameters of a client appliance are known and rendering images when the parameters of a client appliance are unknown. The invention also considers the rendering from the client appliance perspective and the server appliance perspective.

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Plainsboro, NJ, United States of America

Min Xie