Mako Surgical Corporation

Fibrogen, Inc.

Activx Biosciences, Inc.

Min Wu

Lee Allen Flippin

Michael P Arend

Jienan Ding

Hyosig Kang

Eric Douglas Turtle

Peter L Ebbitt

Wen-Bin Ho

Ta-Cheng Chang

Snehal Kasodekar

Jean Gonzalez

Shaojiang Deng

Matt Harrow

Viktor Krebs

Xiaoti Zhou

Robert A Brindley

Louis K Arata

Heng Cheng

Danny Ng

Joseph J Bos

Tim Perez

Saul Najera

David Alan Campbell

Anna Katrin Szardenings

Lee Robert Wright

Hongda Zhao

Marek Liyanage

Wen-bin Ho

Lee R Wright

A method for intraoperatively augmenting a revision implant includes removing a primary implant from a bone, intraoperatively determining a size of a defect of the bone, intraoperatively cutting a bone filler material to the size of the defect, installing the bone filler material at the defect, and installing the revision implant on the bone.

Systems and methods for guiding a revision procedure

A method for intraoperative planning and facilitating a revision arthroplasty procedure includes displaying a virtual model of a bone, capturing positions of a tracked probe as the tracked probe contacts points at a perimeter of a primary implant component coupled to the bone, generating a virtual representation of an interface between the primary implant component and the virtual model of the bone using the positions of the tracked probe, planning a bone resection using the virtual representation of the interface, and guiding execution of the bone resection.

A method of performing a procedure includes preparing a subject, gaining access to a portion of the subject with a first instrument, removing a first portion of the portion of the subject with the first instrument, gaining access to the portion of the subject with a tracked instrument, moving the tracked instrument to a surface revealed by removal of at least the first portion from the portion of the subject, tracking the tracked instrument while moving at least the tracked instrument to the surface, and determining a representation of the surface based on the tracking the tracked instrument.

Systems and methods for a robotic-assisted revision procedure

A fiber optic tracking sensor includes an outer tube, a plurality of optical fibers within the outer tube and including a central optical fiber and a plurality of additional optical fibers, and one or more structural members within the outer tube and configured to provide a spacing between the plurality of optical fibers such that the central optical fiber is positioned along a central longitudinal axis of the outer tube and the plurality of additional optical fibers are spaced apart from one another and from the central optical fiber.

Systems and methods for fiber optic tracking

A method for intraoperatively planning and facilitating a revision arthroplasty procedure. The method includes capturing positions of a tracked probe as the tracked probe contacts an interface area between a bone and a primary implant component implanted on the bone, intraoperatively generating a virtual boundary corresponding to a portion of the interface area to be removed to detach the primary implant component from the bone using the positions of the tracked probe and without use of pre-operative medical imaging, facilitating removal of the primary implant component from the bone by providing a constraint on operation of a cutting tool while the cutting tool removes the portion of the interface area, the constraint based on a relationship between the cutting tool and the virtual boundary.

A fiber optic tracking sensor includes at least three optical fibers, each optical fiber having a plurality of fiber optic sensors along a length of a sensing portion of the sensor. A shape-memory member is coupled to the three optical fibers and provides support to the sensor. The at least three optical fibers are arranged in a spaced apart relationship, each offset from a central longitudinal axis of the sensor.

A method for performing a revision surgery using a robotic-assisted surgery system includes determining information related to an interface area between an implant component and a bone, and generating a planned virtual boundary associated with a portion of the interface area to be removed in a representation of the implant and the bone, based at least in part on the information related to the interface area. The method further includes tracking movement in the physical space of a cutting tool such that movement of the cutting tool is correlated with movement of a virtual tool, and providing a constraint on the cutting tool while the cutting tool removes the portion of the interface area. The constraint is based on a relationship between the virtual tool and the planned virtual boundary. The portion of the interface area is removed to remove the implant component from the bone.

The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias. 

4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors

The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II). 

Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity

The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: 

Cyanoisoquinoline compounds and methods of use thereof

The description relates to surgical computer systems, including computer program products, and methods for cumulative buffering for surface imaging. A display image is buffered that has been saved from a previous update. A model representing a tool is subtracted from the buffered display image. The subtracted display image is displayed using a CSG technique at a fixed angle. The subtracted display image is saved. This process is repeated so that the displayed image is cumulatively changed with each change in location of the model representing the tool.

Cumulative buffering for surface imaging

The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.

Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions

Described are computer-based methods and apparatuses, including computer program products, for automatic image segmentation using contour propagation. A path metric of a candidate piece of a contour in a cross-sectional image is calculated to generate a three dimensional model using a plurality of cross-sectional images of an object. Data indicative of the cross-sectional image is stored. A cost of each of a plurality of pixels associated with the candidate piece is calculated using the data, wherein the cost is representative of a likelihood the pixel is on the contour and the cost is based on one or more templates. An orientation change value is calculated for each of the plurality of pixels associated with the candidate piece based on an initial pixel of the candidate piece and the pixel. A ratio of pixels is calculated. The path metric of the candidate piece of the contour is stored, the value of the stored path metric being based on the calculated cost, the calculated orientation change value, and the calculated ratio.

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Fort Lauderdale, FL, United States of America

Min Wu