University of California

Cedars-Sinai Medical Center

Min Song

Hsian-Rong Tseng

Leland W K Chung

Ker-Chau Li

Shuang Hou

Libo Zhao

Edwin M Posadas

Yi-Tsung Lu

Jake Lichterman

Jiefu Chen

Mitch A Garcia

Hao Ho

Tom Lee

Jiaoti Huang

Zunfu Ke

A method, system and computer-readable medium for assessing a disease condition of a cancer of a subject, including: receiving a blood sample from the subject; isolating a plurality of circulating tumor cells (CTCs) from the blood sample; measuring at least one of cell or cell nucleus sizes of each of the plurality of CTCs; determining a measured CTC size distribution of the plurality of CTCs based on the measuring; comparing the measured CTC size distribution to a reference CTC size distribution using a computer; and assigning the disease condition of the cancer of the subject based on the comparing.

Method of assessing disease condition of cancer

A system for isolating preselected cell types from a fluid sample that includes a plurality of cell types includes a cell-capture fluidic chip, and a chip holder configured to receive the cell-capture fluidic chip and to maintain the cell-capture fluidic chip with a substantially fluid-tight seal while in operation. The chip holder is further configured to release the cell-capture fluidic chip to be removed from the chip holder for further processing. The cell-capture fluidic chip includes a substrate, a laser micro-dissection membrane disposed on the substrate, and a channel-defining layer disposed on the laser micro-dissection membrane. The laser micro-dissection membrane has a surface adapted to capture preselected cell types preferentially over other cell types of the plurality of cell types. The channel-defining layer is removable from the laser micro-dissection membrane for further processing of the cell-capture fluidic chip.

Systems, methods and components for isolating cells from a fluid sample

Growing community of inventors

Los Angeles, CA, United States of America

Min Song