Scinopharm Taiwan, Ltd.

Vita Genomics, Inc.

Min-Pey Ding

Wei-Kuang Liu

Jui-Lin Chen

Pei-Jer Chen

Kuei-Ling Chen

Ding-Shinn Chen

Yuchi Hwang

Kuang-Den Chen

Ming-Yang Lai

Wen-Pi Chu

Shu-Ching Wang

Wan-Lin Yao

A method for screening cells with high level expression of a target protein is disclosed. The method includes introducing into a plurality of host cells a DNA construct that encodes both a target protein and an inhibitor to an endogenous selectable marker in the host cells, screening host cells harboring the DNA construct for the expression of the endogenous selectable marker, and isolating cells with reduced expression of the selectable marker. Also disclosed is a DNA construct configured to express both the target protein and the inhibitor inside the host cell.

Inhibition-based high-throughput screen strategy for cell clones

Vector for inhibition-based high-throughput screen strategy

It is provided isolated polynucleotides that include sequences from genomic region around the gene CD 81. The polynucleotides include polymorphisms associated with treatment response of HCV patients to interferon-&#x3b1; and ribavirin combined therapy and are useful as the probes in screening for patients who will response to interferon-&#x3b1; and ribavirin combined therapy. It is further provided linkage disequilibrium structure of the CD81 gene and haplotype information within a particular LD block, which can be used for prediction of the treatment outcome of the interferon-&#x3b1; and ribavirin combined therapy on HCV patients.

Method for detecting a propensity of an individual to respond effectively to treatment of interferon-&#x3b1; and ribavirin combined therapy

Growing community of inventors

Taipei, Taiwan

Min-Pey Ding