University System of Maryland

Shionogi Pharma, Inc.

Min Michael He

Moise A Khayrallah

Ngoc Do

Larry Augsburger

Cheng Der Tony Yu

Henry Joseph Horacek

Novel methods for making dosages form comprising a cushioning component. The methods of the present invention provides dosage forms which can be compressed to form compressed dosage forms that are substantially uniform in composition and robust and exhibit reduced friability. The invention also relates to methods for making fast-disintegrating dosage forms.

Methods for making pharmaceutical dosage forms containing active cushioning components

A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a a2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the a2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.

Extended release formulation and method of treating adrenergic dysregulation

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Ellicott City, MD, United States of America

Min Michael He