Roche Diagnostics Operations, Inc.

Shanghai Institute of Pharmaceutical Industry

Shanghai Synergy Pharmaceutical Sciences, Ltd.

Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Li, Min

Min Li

Yu Huang

Zhedong Yuan

Hanbin Shan

Xiong Yu

Robert Sundoro Wu

Jane S C Tsai

Provided herein are novel compounds of Formula I, or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising the same. Also provided are methods of preparing the compounds of Formula I, or pharmaceutically acceptable salt thereof. Further provided are methods of using the novel compounds of Formula I, or a pharmaceutically acceptable salt thereof, for example, for inhibiting thrombin and/or for the use in the prevention and/or treatment of thrombin-mediated and thrombin-related diseases.

Dipeptide compounds and uses thereof

Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and applications in the treatment and prevention of thrombin-mediated and thrombin-related diseases.

Prolinamide derivatives as thrombin inhibitors, preparation method and application thereof

A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I):G-(L)&#x2014;Y;&#x2003;&#x2003;(I)where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as &#x2014;SO, &#x2014;NR&#x2014;SO, &#x2014;P(&#x2550;O)(OH)(O), or &#x2014;O&#x2014;P(&#x2550;O)(OH)(O); where R is H or an alkyl group of 1 to 10 carbon atoms.

Water-soluble derivatives of lipophilic drugs

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Ringoes, NJ, United States of America

Min Li