Korea Research Institute of Bioscience and Biotechnology

Leadbio, Inc.

Bioholdings Co., Ltd.

Min-Jeong Sohn

Sang-Ki Rhee

Jeong-Yoon Kim

Hyun-Ah Kang

The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encodingyapsin1, a polypeptide encoded by the nucleic acid molecule, amutant strain having reduced yapsin activity by mutation of the HpYPS gene encodingyapsin1, a recombinantstrain expressing a foreign protein produced by introducing a gene encoding the foreign protein into themutant strain, and a process for preparing a foreign protein comprising culturing the recombinantstrain under conditions to express the foreign protein and isolating the foreign protein from the culture.

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Daejeon, South Korea

Min-Jeong Sohn