Samyang Corporation

Samyang Biopharmaceuticals Corporation

Other

Sam Yang Co., Ltd.

Expression Genetics, Inc.

Samyang Holdings Corporation

Min-hyo Seo

Young-hoon Cho

In-ja Choi

Min-Hyo Seo

In-Ja Choi

Sa-Won Lee

Bong-Oh Kim

Ji-Yeon Son

Yil-Woong Yi

Myung-Seob Shim

Joong-Woong Cho

Gyeong-Hae Kim

Chaul-Min Pai

Sang-Jun Lee

Jong-Sang Park

Muhn-Ho La

Hye Yeong Nam

Sung-Won Choi

Jae-Won Yu

Dong-Hoon Chang

Hye-Won Kang

Se-Ho Kim

Sang Hoon Kim

Seung-Jin Lee

Bong Oh Kim

Guw-Dong Yeo

Ji-Hye Choi

Jeong-Kyung Kim

Hye-Jeong Yoon

Jeong-Il Yu

Myung Seob Shim

Jong-Pyoung Jung

You-Chan Kim

Seok-Joon Yoon

Jae-Yong Lee

Jee-Hyang Kim

Myung-Han Huyn

Jae-Hong Kim

Young-Hoon Cho

Hee-Jo Kim

Myung-Han Hyun

Sang-Hee Kim

Sungwon Choi

Han-Uk Kong

Jung-Il Yu

Disclosed are a pharmaceutical composition for anionic drug delivery, and a preparation method therefor, the pharmaceutical composition for anionic drug delivery containing: an anionic drug as an active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the anionic drug formed a complex with the cationic lipid, and the complex is encapsulated within a micelle structure formed by the amphiphilic block copolymer and the polylactate.

Pharmaceutical composition containing anionic drug, and preparation method therefor

Disclosed is a method capable of selectively synthesizing cationic lipids by controlling the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of reaction conditions.

Method for selectively synthesizing cationic lipids

Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.

Stabilized pharmaceutical composition and method for preparing same

Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation without use of an antioxidant. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.

Pharmaceutical composition not containing antioxidant and preparation method therefor

Disclosed are an anionic drug-containing polymeric micelle particle comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The particle may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.

Polymeric micelle particle comprising anionic drugs and method of preparing the same

A method for stabilizing a poorly water-soluble drug-containing amphiphilic block copolymer micelle composition via simplified steps in short time is described. Also described is a stabilized poorly water-soluble drug-containing amphiphilic block copolymer micelle composition having improved stability.

Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug

Disclosed are a polymeric drug carrier-containing pharmaceutical composition with enhanced stability in its solution state and a method for stabilizing the same. More particularly, disclosed are a pharmaceutical aqueous solution composition for storage under refrigeration containing a polymeric drug carrier comprising an amphiphilic block copolymer comprised of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative fixed with a di- or tri-valent metal ion at its terminal carboxyl group and having preservation stability for at least 6 months, preferably at least 12 months when stored under refrigeration, and a method for stabilizing the same.

Polymeric nanoparticle solution composition and its manufacturing process

Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.

Carrier for negatively charged drugs comprising a cationic lipid and a preparation method thereof

Disclosed are a highly pure amphiphilic block copolymer including a hydrophobic polymer block of a poly(&#x3b1;-hydroxy acid), and a method for preparing the same. The method for preparing a highly pure amphiphilic block copolymer including a hydrophobic polymer block of a poly(&#x3b1;-hydroxy acid) includes removing &#x3b1;-hydroxy acid, lactone monomers thereof, oligomers thereof and an organometal catalyst in polymerizing the amphiphilic block copolymer.

Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof

Polylactic acid derivatives capable of forming micelles in an aqueous solution with a pH of 4 or above, having one terminal carboxyl group. The polylactic acid derivatives may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.

pH responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery

The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: &#x3c;formula 1&#x3e; 1-(R&#x2014;X)wherein each of X, R, I and n is defined as in the detailed description.

Biodegradable branched polylactide derivatives capable of forming polymeric micelles, and their preparation method and use

Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group. The carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion, obtained by adding the di- or tri-valent metal ion to the polymeric composition.

Polymeric micelle compositions with improved stability and methods of making thereof

The present invention relates to an ionic multi-block copolymer composition comprising tri-block copolymers having a polypropyleneoxide or polybutyleneoxide block positioned between two polyethyleneoxide blocks and the tri-block copolymers are connected through dicarboxylic acid linkages forming a multi-block copolymer having a weight average molecular weight of more than 40,000 Dalton. The higher weight average molecular weight enables the hydrolgel formed from the multi-block copolymer of the present invention to maintain its gel status for more than several days.

Biodegradable multi-block polymeric composition capable of sol-gel transition and pharmaceutical composition comprising the same

A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium. The present invention also provides an efficient method to effectively incorporate a hydrophobic drug into a polymeric micelle in a polyethylene glycol separating medium.

Method for the preparation of polymeric micelle via phase separation of block copolymer

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Daejeon, South Korea

Min-Hyo Seo