Yang Ji Chemical Co., Ltd.

Han Wha Pharma Co., Ltd.

Min-Ho Oak

Jong-Hoon Kim

Jee Woong Lim

Jung-Ok Lee

Jung-Duk Sohn

Seung-Woo Lee

Chung Keun Rhee

Woon-Sun Choi

Yongho Na

Youna Oh

So-Hee Kang

The present invention relates to a composition for treatment and prevention of cardiovascular diseases, containing an extract of. More particularly, the extract ofstrongly inhibits NAD(P)H oxidases, which are the main cause of vascular diseases, and at the same time, regulates contraction and relaxation of vascular smooth muscles to manifest a potent vasorelaxant effect, thereby improving the blood pressure regulation and vascular endothelial dysfunction. Therefore, a composition containing this as an active ingredient can be usefully utilized as a pharmaceutical product or health functional food product for the prevention and treatment of cardiovascular diseases.

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The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma, and various diseases related to CCR2. wherein R, R, R, R, R, R, R, Rand Ris the same as defined in the specification.

Piperazinyl 3-aminopyrrolidine derivatives as a CCR2 antagonists

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Gyeonggi-do, South Korea

Min-Ho Oak