Chinese Academy of Sciences

Lear Corporation

Min Gu

Fajun Nan

Jianping Zuo

Wei Tang

Yangming Zhang

Jian Ding

Jia Tao Li

Qian Zhu

Ying Xue

Haijun Chen

XiaoZhong Wu

Linghua Meng

Yihua Chen

Mingzhe Zhao

Fenghua Zhu

Huajie Zhang

Guifeng Wang

Na Yang

Yahui Zhang

Linqian Yu

Jia Li

An armrest assembly includes an armrest and a lid mounted on the armrest for relative rotational movement between a closed and open positions. The lid includes a handle cradle with handle guides on opposed sides and an intermediate inner guide. A handle is located in the handle cradle for relative movement between a latch position and a release position. The handle includes a latch. The latch retains the lid in the closed position when the handle is in the latch position. The handle includes a clip that engages a slot on the lid to retain the handle in the handle cradle. The handle also includes guide channels on opposed sides. The guide channels engage the handle guides. The handle includes an intermediate inner guide space. The inner guide space engages the inner guide. The armrest assembly also includes a spring that biases the handle into the latch position.

Armrest assembly with lid with latch release handle

The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on. 

Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents

Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl. 

Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof

The present invention discloses a novel method for preparing and purifying 4-(6-Amino-purin-9-yl)-2(S)-hydroxy-butyric acid methyl ester. The preparation started from cheap and easily available L-malic acid, which was transformed to intermediate I after simultaneous protection of the groups of 1-carboxyl and 2-hydroxyl. The intermediate I was selectively reduced to intermediate alcohol II, whose hydroxyl group was further transformed to an easily leaving group to afford intermediate III. The intermediate III was nucleophilically substituted with adenine to afford intermediate IV. The intermediate IV was deprotected and methyl-esterified simultaneously in methanol in the presence of an acid or a base to afford crude 4-(6-Amino-purin-9-yl)-2(S)-hydroxy-butyric acid methyl ester, which was purified by recrystallization to afford the purified product. Comparing with the prior preparation methods, the present method has advantages in low cost, mild conditions, high retention of the chiral center during the reaction, high productivity, great improvement in the quality and yield of the product and great decrease in cost, and thus is suitable for the production on a large scale.

Method for preparing 4-(6-amino-purin-9-YL)-2(S)-hydroxy-butyric acid methyl ester

The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzheimer's disease, apoplexy and brain ischemic injuries.

Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof

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Shanghai, China

Min Gu